Your Ketamine Infusion: What to Expect

Ketamine infusion therapy is a medical procedure administered in a clinical setting for certain conditions, including treatment-resistant depression and chronic pain. This therapy involves the intravenous delivery of ketamine at low, controlled doses. It aims to provide relief by affecting brain receptors and promoting new neural connections. The experience is supervised by medical professionals who monitor patient well-being throughout the process.

Getting Ready for Your Ketamine Infusion

Preparing for a ketamine infusion involves several practical steps. Patients are advised to fast for a specific period before their appointment, avoiding solid foods for 4 to 8 hours and clear liquids for 2 hours prior to the infusion to minimize nausea. Patients must also discuss all current medications with their healthcare provider, as some, like benzodiazepines or opioids, may need temporary adjustment or discontinuation.

Patients should wear comfortable, loose-fitting clothing, as they will be seated in a reclining chair during treatment. Arranging for transportation home by a responsible adult is important, as patients cannot drive or operate machinery for at least 24 hours after the infusion. Bringing personal items like headphones with calming music or an eye mask can also enhance comfort during the session.

The Infusion Experience

During a ketamine infusion, patients relax in a quiet, comfortable room with dim lighting, often in a reclining chair. A medical professional will insert a small intravenous (IV) line, usually in the arm or hand, to administer the ketamine. The medication is delivered slowly over a period ranging from 40 to 60 minutes.

Throughout the infusion, medical staff continuously monitor vital signs such as blood pressure, heart rate, and oxygen levels to ensure patient safety. Patients remain conscious during the procedure, though they may experience various sensory and cognitive effects. Common sensations include a feeling of detachment or an “out-of-body” experience, lightheadedness, or a sense of floating.

Some individuals report visual distortions, altered perception of time, or vivid, dream-like states. These experiences are temporary and vary between individuals and sessions. While some find the sensations pleasurable or introspective, any discomfort can be managed by the medical team.

Immediately After Your Infusion

Following the ketamine infusion, patients move to a recovery area for observation. This immediate recovery phase lasts between 15 minutes to an hour, allowing the initial effects of the medication to subside. During this time, temporary effects like grogginess, dizziness, or mild disorientation are common.

Nausea is another side effect, though it is managed with anti-nausea medications by staff. Patients may also experience temporary issues with balance or coordination. Due to these lingering effects, it is advised that patients do not drive, operate heavy machinery, or make important decisions for the day.

Post-Infusion Care and Follow-Up

For the rest of the day following a ketamine infusion, it is important to prioritize rest and avoid strenuous activities. While some individuals may feel energized, others might experience fatigue, making adequate sleep beneficial for recovery. Staying well-hydrated is also recommended, and a light, easily digestible meal can be consumed once any nausea has subsided.

Patients should communicate any lingering mild effects or concerns to their clinic. Follow-up appointments are scheduled to assess progress and adjust future treatment plans, especially if the infusion is part of a series. Continued self-care practices, such as mindfulness, a healthy diet, and gentle exercise, can further support the benefits of the therapy.