Which STDs Cause Epididymitis? Symptoms and Prevention

Epididymitis is the inflammation of the epididymis, the coiled tube at the back of the testicle that stores and transports sperm. This condition causes discomfort and pain in the scrotum and is often linked to a bacterial infection. In sexually active males under 35, the most common causes are pathogens transmitted through sexual contact. Effective management requires understanding the pathogens, recognizing symptoms, and following preventative steps.

Identifying the STD Causes

The majority of acute epididymitis cases in young men are caused by sexually transmitted pathogens that ascend the genitourinary tract. The two organisms most often implicated are Chlamydia trachomatis and Neisseria gonorrhoeae, which account for a significant portion of cases in men under 35. These bacteria typically begin as an asymptomatic infection in the urethra and then travel backward through the vas deferens to infect the epididymis.

Chlamydia trachomatis often causes infections with few or no initial symptoms, allowing the bacteria to progress until they cause complications like epididymitis. STD-related epididymitis is often accompanied by urethritis, which is inflammation of the urethra. Other bacteria, such as Escherichia coli, can also cause epididymitis, especially in men over 35 or those who have insertive anal sex.

Recognizing the Symptoms

STD-related epididymitis typically involves discomfort that gradually worsens over several days. Individuals usually experience pain and tenderness localized to one side of the scrotum, corresponding to the inflamed epididymis. The affected area may also exhibit noticeable swelling, warmth, and redness as the inflammation progresses.

The physical signs can spread to involve the testicle itself, a condition known as epididymo-orchitis. Systemic signs of infection, such as a low-grade fever or chills, may also occur. Since the infection often starts in the urethra, symptoms like painful urination, urinary frequency, or penile discharge may be present. If pain is sudden and severe, immediate medical attention is required, as these symptoms can overlap with testicular torsion, a medical emergency.

Medical Diagnosis and Necessary Treatment

Diagnosis begins with a thorough physical examination where a healthcare provider checks the scrotum for tenderness and swelling of the epididymis. Laboratory testing is performed to identify the specific causative organism, which guides the correct treatment. This testing typically involves nucleic acid amplification tests (NAAT) conducted on a urine sample or a urethral swab to screen specifically for Chlamydia trachomatis and Neisseria gonorrhoeae.

In some cases, an ultrasound with color Doppler imaging may be performed to visualize the testicle and epididymis. This imaging technique is helpful because it can differentiate epididymitis from other serious conditions like testicular torsion, by confirming an increase in blood flow to the affected area rather than a decrease. Given the potential for complications, treatment is usually started empirically before test results are finalized, targeting the most likely pathogens.

The standard treatment for suspected STD-related epididymitis involves a combination of antibiotics, typically a single injection of Ceftriaxone to address possible gonorrhea, paired with a 10-day course of oral Doxycycline for chlamydia. Completing the entire course of prescribed antibiotics is necessary to ensure the infection is fully eradicated, even if symptoms begin to clear up sooner. Supportive care measures are also recommended, including bed rest, elevating the scrotum, and using anti-inflammatory pain relievers to manage discomfort and swelling. Individuals must also ensure that all recent sexual partners are notified and treated to prevent reinfection and limit further transmission of the bacteria.

Strategies for Prevention

Prevention focuses on avoiding the sexually transmitted infections that cause epididymitis. The consistent and correct use of barrier methods, such as external condoms, during all types of sexual activity significantly lowers the risk of contracting Chlamydia and Gonorrhea. Using barrier methods for oral, vaginal, and anal sex creates a physical barrier that helps block the exchange of infectious fluids.

Regular screening is a necessary preventative measure, especially for sexually active individuals with new or multiple partners, or those who do not consistently use barrier methods. Since infections like chlamydia are often asymptomatic, routine testing allows for early detection and treatment before the bacteria can migrate and cause complications like epididymitis. Open communication with partners about sexual health history and status is also a protective step, allowing individuals to make informed decisions about safe practices.