Dihydromyricetin (DHM) is a naturally occurring flavonoid compound derived primarily from the Japanese Raisin Tree. This plant has a history of use in traditional East Asian practices, where extracts were commonly used as a “sobering” agent and for liver support. Modern science has isolated DHM as the active component responsible for these purported effects.
Primary Uses and Mechanism of Action
Consumers frequently seek out DHM for its potential to manage the effects of alcohol consumption, including mitigating hangover symptoms and reducing acute intoxication. DHM appears to function through a two-pronged mechanism involving both the brain and the liver.
In the brain, DHM is believed to interact with Gamma-Aminobutyric Acid (GABA-A) receptors, which are the same receptors that alcohol targets to produce its sedating effects. By acting as a competitive antagonist, DHM may help block alcohol from fully activating these receptors, which could reduce the impaired coordination and motor function associated with intoxication. Early preclinical studies suggest that DHM may help accelerate the return to normal function following alcohol exposure.
In the liver, DHM appears to promote the faster processing of alcohol and its toxic byproducts. Alcohol is first metabolized into acetaldehyde, and then into harmless acetate. Research suggests DHM may enhance the activity or expression of the liver enzymes Alcohol Dehydrogenase (ADH) and Aldehyde Dehydrogenase (ALDH), which are responsible for these metabolic steps. Additionally, DHM exhibits anti-inflammatory and antioxidant properties, which help protect liver cells from oxidative stress and injury caused by chronic alcohol exposure.
Forms, Dosage, and Timing
Dihydromyricetin is widely available in several forms. The most common formats are capsules, which offer convenience and precise dosing, and bulk powder, which allows for customization. DHM can also be found in pre-mixed beverage formulas and complex supplement blends.
Dosage guidelines are generally based on body weight and the amount of alcohol consumed, with clinical studies often using a range between 300 to 1,000 milligrams per serving. For optimal results related to alcohol consumption, the timing of intake is considered important. DHM is typically recommended to be taken shortly before, during, or immediately after consuming alcohol, rather than waiting until the next morning.
Navigating the Market and Reputable Sources
Finding a high-quality DHM supplement requires careful scrutiny of the vendor and product labeling. Consumers should prioritize brands that demonstrate transparency and provide evidence of third-party testing. A Certificate of Analysis (COA) from an independent laboratory is the most reliable indicator of product quality.
A COA should confirm that the supplement contains the stated amount of Dihydromyricetin and is free from common contaminants. These tests specifically check for:
- Heavy metals like lead and mercury.
- Microbial contamination.
- Pesticide residues.
The presence of seals from recognized third-party certification bodies, such as USP or NSF International, further confirms that the product has been audited for purity, potency, and adherence to manufacturing standards.
It is advisable to avoid products that use “proprietary blends” where the DHM is listed as part of a larger mix without disclosing the precise milligram amount. Without knowing the dosage, it is impossible to determine if the product contains enough of the active compound to align with amounts used in scientific research. Purchasing from reputable sources that openly publish their COAs and use clear labeling ensures a verified dose of the active ingredient.
Safety Considerations and Interactions
Dihydromyricetin is generally well-tolerated, and available research indicates a good safety profile in short-term use. Reported side effects are rare and usually mild, occasionally including temporary abdominal discomfort or nausea. However, DHM is a bioactive compound, and precautions should be taken regarding its use alongside prescription medications.
Some in vitro studies suggest that DHM may have the potential to inhibit certain liver enzymes, such as cytochrome P450 (CYP) enzymes. These enzymes metabolize a wide variety of medications, meaning that DHM could potentially alter the effectiveness or increase the concentration of other drugs in the body. Individuals taking any prescription medication should consult with a healthcare professional before adding DHM to their regimen to discuss potential interactions.