Progesterone cream is a topical preparation containing the hormone progesterone. Applied to the skin, it allows progesterone to enter the bloodstream directly, bypassing the initial metabolic processes in the liver that occur with oral ingestion. This direct absorption into the systemic circulation is how these creams deliver progesterone, supplementing the body’s hormone levels.
Primary Application Areas
Progesterone cream is typically applied to areas of the body where the skin is relatively thin and has good blood circulation for effective absorption. Common sites include the inner arms (forearms and wrists) and inner thighs. The neck and chest areas, particularly the upper chest, are also recommended.
Other locations include the abdomen, lower back, ankles, and behind the knees. Absorption rates vary by area; thin-skinned regions like the wrists or neck may offer faster absorption, while areas with more subcutaneous fat, such as the buttocks or outer thighs, can provide a slower, more sustained release. Avoid applying cream to irritated, broken, or excessively hairy skin, as this can hinder absorption and cause discomfort.
Rotating application sites is important when using progesterone cream. Consistently applying to the same spot can saturate skin receptor sites, reducing absorption. Alternating areas, such as switching from the inner arm one day to the inner thigh the next, maintains optimal absorption. Rotation also minimizes local skin irritation from repeated application.
Proper Application Techniques
Prepare the skin before applying progesterone cream. Wash your hands thoroughly with soap and water. Ensure the chosen application area is clean and dry. Avoid using other lotions, oils, or moisturizers on the skin beforehand, as they can create a barrier and interfere with absorption.
Once the skin is prepared, dispense the prescribed or recommended amount of cream onto your fingertips. This amount varies, commonly ranging from a pea-sized to a nickel-sized portion (approximately 1/4 to 1/2 teaspoon), delivering around 20 to 40 milligrams of progesterone. Gently rub the cream into the chosen skin area using circular motions until fully absorbed, typically taking 10 to 15 seconds. If the cream beads up, it may indicate too much was applied or the area is saturated, suggesting a need to apply less or switch sites.
After applying the cream, wash your hands thoroughly to prevent accidental transfer of the hormone to others, especially children or pets. Allow the cream to absorb for at least 30 minutes before swimming or bathing for maximum uptake. Apply the cream once or twice daily, morning or evening, for steady hormone levels.