When Is the Sex of a Fetus Determined?

The determination of a fetus’s sex is a biological process that begins long before any outward signs appear. This intricate process involves a sequence of genetic instructions, cellular differentiation, and hormonal signaling throughout early development. Understanding this progression reveals how a single fertilized cell develops into an individual with distinct biological characteristics.

The Chromosomal Blueprint at Conception

The genetic sex of a fetus is established at conception, during the fusion of the sperm and egg. Human cells contain 46 chromosomes, arranged in 23 pairs, with one pair being the sex chromosomes. The egg cell always contributes an X chromosome. The sperm cell, however, carries either an X or a Y chromosome, and it is the sperm that dictates the genetic sex of the resulting embryo.

If a sperm carrying an X chromosome fertilizes the egg, the embryo will have an XX chromosomal configuration, leading to genetic femaleness. Conversely, if a sperm carrying a Y chromosome fertilizes the egg, the embryo will have an XY chromosomal configuration, leading to genetic maleness. This initial chromosomal pairing acts as the blueprint for subsequent development. While genetic determination occurs instantly, the physical manifestation of sex takes several more weeks to develop.

Early Embryonic Development of Gonads

Following the chromosomal blueprint, the next phase in sex determination involves gonad development. During the fifth to sixth week of gestation, all human embryos possess undifferentiated gonads, which can develop into either testes or ovaries. The presence or absence of a specific gene on the Y chromosome directs this differentiation.

The Sex-determining Region Y (SRY) gene, located on the Y chromosome, is important for male development. If the SRY gene is present, as in XY embryos, it triggers genetic events that cause the undifferentiated gonads to develop into testes. In XX embryos, where the SRY gene is absent, the gonads develop into ovaries. This genetic switch dictates internal gonadal differentiation, laying the groundwork for subsequent hormonal influences.

Hormonal Influence and Genital Development

Once differentiated, the gonads produce specific hormones that drive the development of internal and external reproductive structures. In male fetuses, the developing testes secrete two primary hormones: testosterone and anti-Müllerian hormone (AMH). Testosterone stimulates the Wolffian ducts to develop into internal male reproductive organs, such as the epididymis, vas deferens, and seminal vesicles.

Simultaneously, AMH causes the Müllerian ducts, which would otherwise form female reproductive organs, to regress. The presence of testosterone also leads to the development of external male genitalia, including the penis and scrotum, typically pronounced from around 8 to 12 weeks of gestation. In female fetuses, the absence of the SRY gene means no testes develop, so no testosterone or AMH is produced. This lack of male hormones allows the Müllerian ducts to develop into the fallopian tubes, uterus, and vagina. External female genitalia, such as the clitoris and labia, also form during this period due to the absence of androgenic influence.

Identifying Fetal Sex

While sex determination begins at conception and continues through early embryonic development, identifying a fetus’s sex practically occurs later in pregnancy. The most common method is an ultrasound scan, typically performed during the anatomy scan between 18 and 22 weeks of gestation. At this stage, external genitalia have usually developed sufficiently to be clearly visible.

Ultrasound accuracy depends on factors like fetal position and gestational age. Other methods, though not primarily for sex determination, can reveal fetal sex earlier. Non-Invasive Prenatal Testing (NIPT), performed using a maternal blood sample as early as 10 weeks, analyzes fragments of fetal DNA in the mother’s bloodstream. It can identify the presence or absence of the Y chromosome, indicating fetal sex.

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