What Time of Day Should I Take Lisinopril?

Lisinopril is a medication primarily prescribed to manage high blood pressure, a condition also known as hypertension. It also treats heart failure and improves outcomes after a heart attack. This medication lowers blood pressure, reducing the heart’s workload and supporting its function.

When to Take Lisinopril

Lisinopril is typically taken once daily, with or without food. Consistency is key; taking the medication at the same time each day helps maintain a stable drug level in your body and ensures 24-hour effectiveness.

While studies have explored morning or evening dosing, current evidence shows no significant difference in overall cardiovascular outcomes. Your doctor might suggest taking the first dose at bedtime due to the possibility of initial dizziness. Ultimately, always follow the specific instructions provided by your healthcare professional regarding the precise timing of your daily dose.

How Lisinopril Works in Your Body

Lisinopril belongs to a class of medications known as angiotensin-converting enzyme (ACE) inhibitors. It works by interfering with a natural system in the body that regulates blood pressure. Specifically, it prevents the ACE enzyme from converting angiotensin I into angiotensin II.

Angiotensin II is a powerful substance that causes blood vessels to narrow, leading to increased blood pressure. By blocking its formation, lisinopril causes blood vessels to relax and widen, which directly lowers blood pressure. This mechanism also reduces the production of aldosterone, a hormone that promotes sodium and water retention, further contributing to blood pressure reduction. Lisinopril is a long-acting medication, with effects lasting approximately 24 hours, which is why a single daily dose is effective for consistent blood pressure control.

What to Do About Missed Doses and Other Advice

If you miss a dose of lisinopril, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose entirely and continue with your regular dosing schedule. Never take a double dose to compensate for a forgotten one, as this could increase the risk of side effects.

Regularly monitor your blood pressure. Never stop taking lisinopril abruptly without first consulting your doctor. Common side effects include dizziness or lightheadedness, especially when standing up quickly, which is more likely when you first start the medication or if your dose is increased. Staying well-hydrated is also important, as dehydration can contribute to low blood pressure and associated dizziness.