What Is the Longest Surgery Ever Performed?

A surgical procedure is generally considered long if it extends beyond six hours, the point at which the probability of post-operative complications begins to climb noticeably. These extraordinary operations demand exceptional synchronized effort and technical precision from the entire operating team. The sheer length of these marathon procedures, sometimes lasting days, reflects profound anatomical complexity and the meticulous, step-by-step approach needed to address life-threatening conditions or perform reconstructive miracles.

Procedures Requiring Extreme Duration

The longest surgical procedures are those that necessitate the reconstruction of deeply intertwined or damaged anatomical structures. The most protracted operation on modern record lasted 103 hours, or more than four full days, involving the separation of 11-month-old Nepalese conjoined twins, Ganga and Jamuna Shrestha, in 2001. This was a craniopagus separation, meaning the twins were joined at the head, sharing a cranial cavity and partially fused brains. While conjoined twin separation typically requires around 30 hours, the extended duration was due to the intricate fusion of the girls’ brains and the discovery of hundreds of shared, intertwined blood vessels requiring individual identification and careful separation.

Complex multi-visceral and total body reconstruction operations also require extreme surgical time. Extensive tumor resections, particularly those involving the pelvis or cranium requiring immediate, massive reconstruction, can span 15 to 30 hours. Comprehensive organ transplantation procedures, such as face or bilateral hand transplants, commonly last between 12 and 24 hours. Multi-organ transplantations, like combined heart and lung procedures, often take 8 to 12 hours, dictated by the necessity of replacing multiple major organs sequentially. These procedures involve the re-establishment of numerous vascular and neural connections.

Factors Driving Extended Surgical Time

The primary reason these operations require extended durations is the necessity of microscopic precision for anatomical reconstruction. Surgeons must employ micro-suturing techniques to connect minute blood vessels and nerves, a process performed flawlessly to ensure tissue viability and future function. For example, in the conjoined twins’ separation, the team had to individually coagulate, separate, and divide hundreds of shared blood vessels between the two brains. This task demanded hours of deliberate work under high magnification, as a single error could have catastrophic consequences for the patient.

Many of the longest procedures are multi-stage operations combined into a single, continuous surgical event. For complex transplants, this involves the donor organ first being harvested, followed by preparation of the recipient site, and finally the implantation and connection of the new organ. Each stage has unique technical demands and time requirements, making the overall procedure significantly longer than a standard operation. The patient’s state during massive tissue manipulations requires constant monitoring and immediate adjustment of physiological support. This continuous re-evaluation of vital signs prevents a quickened pace, prioritizing stability over speed.

Logistical Requirements for Marathon Operations

Operations extending past a single workday require a sophisticated logistical framework to ensure continuity. The most crucial element is the rotation of specialized surgical and anesthesia teams. For the 103-hour twin separation, a team of twenty doctors worked in shifts to maintain peak performance and avoid fatigue-related degradation of decision-making. This rotation ensures a fresh, highly skilled expert is always at the operating table, sustaining the required level of precision.

Complex pre-operative planning transitions from helpful preparation into a strict requirement for these marathon procedures. Surgeons utilize advanced imaging and 3D modeling to create virtual reality simulations of the operation. This allows the team to rehearse challenging steps, anticipate complications, and develop contingency plans before the patient is anesthetized. Maintaining a sterile environment is also essential; the operating room must be continuously monitored and refreshed to prevent microbial contamination over multiple days of exposure. Specialized equipment is needed for continuous monitoring of neurological and cardiovascular function, providing real-time data to the rotating team.

Unique Risks of Prolonged Anesthesia and Exposure

The primary risk associated with protracted surgery is the significant increase in the risk of post-operative complications directly linked to time. Studies show that the likelihood of complications significantly increases once a procedure exceeds the six-hour mark. For every additional 30 minutes of operating time, there is approximately a 14% increase in the risk of complications across specialties. This rising risk is partly due to the cumulative stress on the patient’s organ systems from extended exposure to general anesthesia.

The prolonged immobility required during these operations creates specific risks, including an elevated chance of developing deep vein thrombosis (DVT) and severe pressure injuries or nerve damage. Extended anesthesia exposure can also impair the body’s natural thermoregulation, leading to perioperative hypothermia. Hypothermia increases the risk of wound infection, impairs immune function, and contributes to surgical bleeding. The operation’s length also increases the probability of post-operative infection due to the extended exposure of internal tissues, compounded by the immunosuppressive effects of anesthetic agents.