What Is the Difference: Actinic vs. Seborrheic Keratosis?

Skin lesions are common, and understanding their characteristics is important for skin health. Actinic Keratosis (AK) and Seborrheic Keratosis (SK) are frequently encountered. While both involve changes in skin texture and appearance, they are distinct conditions with different implications. Recognizing their specific features helps individuals understand their skin and when to seek medical advice.

Understanding Actinic Keratosis

Actinic keratosis is a rough, scaly patch of skin that develops from prolonged ultraviolet (UV) radiation exposure. These lesions are considered precancerous, with the potential to evolve into squamous cell carcinoma, a form of skin cancer, if left unaddressed. The risk of progression for untreated lesions can be up to 20%.

AK often appears on sun-exposed areas of the body, such as the face, ears, scalp, neck, backs of hands, and forearms. Actinic keratoses typically feel like sandpaper and can vary in color, appearing red, pink, tan, or skin-colored. Their development indicates significant sun damage.

Understanding Seborrheic Keratosis

Seborrheic keratosis is a common, benign skin growth that is non-cancerous. These growths are often described as having a “stuck-on” or “pasted-on” appearance, resembling a wart or a dab of wax. They can range in color from light tan to brown or black and may have a waxy, scaly, or crumbly surface.

SKs are generally harmless and do not transform into skin cancer. These lesions can appear almost anywhere on the body, including the trunk, face, scalp, and neck. Their prevalence tends to increase with age, often appearing in middle age and becoming more numerous over time. While the exact cause is not fully known, genetics and aging are believed to play a role in their development.

Distinguishing Between the Conditions

The primary distinction between actinic keratosis and seborrheic keratosis lies in their nature: AK is a precancerous lesion, while SK is benign. AKs form due to chronic UV light exposure, indicating sun damage. In contrast, seborrheic keratoses are associated with aging and genetic predisposition.

Actinic keratoses are typically rough, dry, and scaly, often feeling like sandpaper. Seborrheic keratoses, however, usually possess a waxy, greasy, or sometimes crumbly surface, often appearing raised and distinctively “stuck-on” to the skin.

AKs are often flatter, scaly patches, sometimes with a horny crust. SKs are typically raised, can be quite pigmented, and have a more defined border.

The progression of these conditions also varies significantly. Actinic keratosis carries a risk of developing into squamous cell carcinoma if not treated. Seborrheic keratosis, on the other hand, has no malignant potential and does not pose a cancer risk.

While both can be found on sun-exposed areas, AK is almost exclusively found there, reflecting its solar origin, whereas SK can appear on any part of the body, excluding palms and soles.

When to Consult a Healthcare Professional

Professional evaluation by a healthcare provider, such as a dermatologist, is recommended for any new or changing skin growth. This is especially true if a lesion changes in size, shape, or color, or if it bleeds, itches, or becomes painful. Early detection of AK allows for timely treatment, which can prevent its progression to skin cancer.

A healthcare provider can visually examine the lesion and may use a magnifying tool for a closer look. In cases where there is uncertainty about the diagnosis or a concern for malignancy, a skin biopsy may be performed. This involves taking a small tissue sample for microscopic examination to confirm the exact nature of the growth.

While SKs are harmless, they can be removed if they cause irritation or for cosmetic reasons, while treatment for AK is often recommended due to its precancerous nature.