What Is the CPT Code for a Screening Colonoscopy?

Medical billing uses Current Procedural Terminology (CPT) codes to communicate services to insurance companies. Understanding the specific CPT code for a screening colonoscopy is important for patients estimating out-of-pocket costs and ensuring proper insurance coverage. The code submitted signals to the payer exactly what service was performed, and the choice of code directly impacts whether the procedure is covered as preventive care or subject to deductibles and co-payments. Colonoscopy billing is complex because the procedure can shift its clinical purpose mid-stream, moving from a simple screening to a more involved diagnostic or therapeutic service.

The Specific Codes for Screening

The CPT code most commonly associated with a screening colonoscopy for commercial insurance is 45378, which is the code for a flexible diagnostic colonoscopy. This code is used for screening when paired with the proper diagnosis code: International Classification of Diseases, Tenth Revision (ICD-10) code Z12.11, indicating an “Encounter for screening for malignant neoplasm of colon.”

Medicare uses a different set of codes known as Healthcare Common Procedure Coding System (HCPCS) codes, often referred to as G-codes. The code G0121 is used for a screening colonoscopy on an average-risk individual, while G0105 is reserved for high-risk patients. These G-codes are specific to the Medicare population and differentiate a screening from other procedures. Regardless of the code used, the inclusion of the screening diagnosis code Z12.11 establishes the intent of the procedure as preventive care.

Differentiating Screening and Diagnostic Procedures

The distinction between a screening colonoscopy and a diagnostic colonoscopy is the foundation of insurance coverage issues and hinges entirely on the patient’s health status leading up to the procedure. A screening colonoscopy is performed on an asymptomatic individual who has no current signs or symptoms of colorectal disease. The sole purpose of this procedure is to prevent cancer by detecting it early or finding pre-cancerous growths. The intent of the procedure is documented using the ICD-10 code Z12.11.

In contrast, a diagnostic colonoscopy is performed when a patient already has symptoms, such as unexplained abdominal pain, rectal bleeding, or a positive result from a stool-based test. These symptomatic cases require the use of a different set of ICD-10 codes, such as those beginning with ‘K’ for digestive system diseases, which changes the procedure’s billing classification.

When a procedure is classified as diagnostic, it is no longer considered a purely preventive service under Affordable Care Act (ACA) guidelines. This means the patient is responsible for cost-sharing, including co-payments and deductibles, even if a polyp is not found. The initial reason for the procedure determines the primary diagnosis code and, ultimately, the patient’s financial responsibility.

When a Screening Procedure Changes Scope

The most common source of billing confusion for patients is when a screening procedure is converted into a therapeutic one. This happens when the gastroenterologist finds and removes a polyp or takes a biopsy of a suspicious lesion during the initial screening. The detection and removal of these incidental findings shift the procedure’s nature from purely preventive to therapeutic, which is reflected in a change of the CPT code.

If a polyp is removed using hot biopsy forceps, code 45384 is used. Removal by a snare technique, which is common for larger polyps, is coded as 45385. These codes describe the physical act of polyp removal, which is a therapeutic intervention that replaces the initial screening code. The new code signifies that a treatment was performed, even though the original intent was preventive screening.

The use of therapeutic CPT codes like 45384 or 45385 can lead to a patient being billed for services expected to be covered at no cost. This is because some insurance plans may classify the polyp removal portion as a separate, non-preventive service, subjecting it to cost-sharing. Specific billing modifiers are intended to communicate the full context of the procedure to the insurer.

The Role of Billing Modifiers in Coverage

Billing modifiers are two-digit codes appended to the CPT code to provide additional context about the procedure to the insurance payer. Two modifiers are important for ensuring correct coverage when a screening converts to a therapeutic procedure.

Modifier 33 (Preventive Service)

Modifier 33 is used primarily for commercial insurance claims. It signals that the service was performed for preventive reasons, as defined by the U.S. Preventive Services Task Force (USPSTF).

Modifier PT (Converted Procedure)

The modifier PT, which stands for “Colorectal Cancer Screening Test; converted to diagnostic test or other procedure,” is used specifically for Medicare beneficiaries. When a polyp is removed during a Medicare screening colonoscopy, the therapeutic CPT code (e.g., 45385) is submitted with the PT modifier attached. This informs Medicare that the procedure began as a screening, allowing the patient to avoid the deductible for the procedure.

Correctly applying these modifiers prevents unexpected out-of-pocket costs. For instance, if a commercial insurer receives CPT code 45385 (polyp removal) with the screening diagnosis code Z12.11 and modifier 33, it clearly signals that the service began as a preventive screening.