Naltrexone is a medication used to support individuals in recovery from alcohol use disorder (AUD) and opioid use disorder (OUD). The optimal time to take naltrexone varies based on individual circumstances and the condition being treated. Consulting a healthcare provider is important to determine the best dosing schedule.
Understanding Naltrexone’s Mechanism
Naltrexone functions as an opioid antagonist, blocking opioid receptors in the brain. This action helps reduce alcohol cravings by preventing natural endorphins from binding to these receptors, diminishing alcohol’s rewarding effects. For opioid use disorder, naltrexone blocks the euphoric effects of opioids, preventing them from activating the brain’s reward pathways.
Dosing Time for Alcohol Use Disorder
For individuals managing alcohol use disorder, naltrexone is typically prescribed as a 50 mg oral tablet once daily. Taking it at a consistent time each day can help maintain its therapeutic effects throughout a 24-hour period. Some individuals may find it beneficial to take the medication approximately an hour before anticipated drinking, as this can help reduce cravings and the pleasurable effects of alcohol. This approach aims to lessen alcohol consumption and support efforts to reduce or stop drinking. Taking naltrexone with food can help mitigate potential gastrointestinal side effects such as nausea.
Dosing Time for Opioid Use Disorder
When naltrexone is used for opioid use disorder, it is important that opioids have been fully cleared from the body before starting treatment. Individuals must be opioid-free for 7 to 10 days for short-acting opioids, and 10 to 14 days for long-acting opioids, to prevent severe withdrawal symptoms. Once abstinence is confirmed, the typical oral dosage is 50 mg once daily. This consistent daily dosing ensures a continuous blockade of opioid receptors, helping prevent the effects of opioid use and supporting relapse prevention.
Adjusting Your Dosing Schedule
Maintaining consistency in taking naltrexone daily is important for its effectiveness. If side effects like nausea occur, taking the medication with food can help reduce discomfort. For those experiencing fatigue or dizziness, adjusting the dosing time to the evening might allow them to sleep through these initial effects. If a dose is missed, take it as soon as remembered; however, if it is almost time for the next dose, skip the missed dose to avoid taking too much medication. Any concerns about side effects or adjusting the dosing schedule should be discussed with a healthcare provider.