Nicotinamide adenine dinucleotide (NAD+) therapy aims to support cellular health and function by boosting NAD+ levels within the body. NAD+ is a fundamental coenzyme present in all living cells, playing a significant role in numerous biological processes.
Understanding NAD+
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme crucial for various metabolic functions. It exists in two forms: NAD+ (oxidized) and NADH (reduced), converting between them to facilitate energy generation. NAD+ acts as an electron carrier in redox reactions, essential for converting nutrients into the energy cells need to function.
Beyond energy production, NAD+ supports other cellular processes, including DNA repair and gene expression regulation. It is a necessary component for enzymes like sirtuins and poly-ADP-ribose polymerases (PARPs), involved in maintaining genomic stability and regulating cellular metabolism. However, NAD+ levels naturally decrease with age, with a reported decline of about 50% by age 40 and up to 80% by age 60. This reduction is influenced by factors such as increased activity of NAD+-consuming enzymes like CD38 and PARPs, oxidative stress, and DNA damage.
What is NAD+ Therapy?
NAD+ therapy is a medical strategy focused on increasing NAD+ levels within the body. This therapy aims to counteract the natural decline of NAD+ that occurs with aging and various stressors. Elevating NAD+ concentrations supports and enhances cellular function, metabolism, and repair processes.
The goal of NAD+ therapy is to optimize cellular health, promoting overall well-being. It seeks to provide cells with the necessary resources to perform their functions more efficiently, including energy production and DNA maintenance. This approach supports the body’s natural resilience and its ability to maintain healthy physiological processes.
Forms of NAD+ Therapy and Their Applications
NAD+ therapy can be administered through several methods. Intravenous (IV) infusions directly deliver NAD+ into the bloodstream, bypassing the digestive system for rapid absorption. Oral supplements, often containing NAD+ precursors like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), are converted into NAD+ once inside the body. Topical creams and nasal sprays represent other forms, with nasal sprays potentially offering a quicker route to the brain.
These therapies support various physiological areas. They are often used to support energy levels, as NAD+ is central to cellular energy production and can help reduce fatigue. Applications also include supporting neurological health, with some forms like nasal sprays designed for targeted delivery to the brain for mental clarity and focus. NAD+ therapy also supports metabolic balance and cellular repair, contributing to overall cellular resilience and function.
Important Considerations for NAD+ Therapy
Individuals considering NAD+ therapy should consult with a qualified healthcare professional. This consultation helps determine suitability and ensures the therapy aligns with individual health needs. Healthcare providers can offer guidance on the most appropriate form and dosage.
While generally considered safe, some individuals may experience temporary and mild side effects. These can include nausea, stomach discomfort, or headaches. For IV infusions, discomfort or redness at the injection site is also possible. Responses to NAD+ therapy can vary significantly, and it may not be effective for everyone.