Deglycyrrhizinated Licorice (DGL) is a specialized herbal supplement derived from the licorice plant, Glycyrrhiza glabra. This preparation is widely popular for its use in supporting and maintaining digestive tract health, particularly the lining of the stomach and esophagus. For centuries, the whole licorice root has been used in traditional wellness practices for its soothing properties. Today, DGL is commonly sought out as a natural approach to manage occasional gastric discomfort and promote the body’s natural defense mechanisms in the gut.
DGL Versus Traditional Licorice Root
The defining characteristic of DGL is the removal of the compound glycyrrhizin, which naturally occurs in the licorice root. Glycyrrhizin is the component responsible for the sweet flavor of licorice. It is also the substance linked to potential adverse effects when whole licorice is consumed in high amounts or for long periods. The main concern with glycyrrhizin is its ability to affect the body’s electrolyte and blood pressure regulation, potentially leading to elevated blood pressure, fluid retention, and decreased potassium levels. By removing this compound through a specific extraction process, DGL is considered a much safer alternative for consistent use in digestive support.
Mechanism of Action: How DGL Protects the Gut Lining
DGL promotes digestive comfort without suppressing stomach acid production like many conventional treatments. Instead, DGL works by stimulating the body’s natural protective and healing processes within the gastrointestinal tract, strengthening the mucosal barrier that lines the stomach and esophagus. The supplement encourages the production and release of protective mucus, a thick, gel-like substance that acts as a physical shield against stomach acid and digestive enzymes. DGL also promotes the growth and repair of mucosal cells. Furthermore, DGL enhances blood flow to damaged areas of the digestive lining, delivering necessary nutrients and promoting the synthesis of prostaglandins that aid in tissue repair.
Therapeutic Applications of DGL
DGL is commonly used to address upper gastrointestinal complaints where the mucosal lining is compromised or irritated. It is frequently recommended for managing the symptoms associated with functional dyspepsia, which is chronic or recurrent pain and discomfort in the upper abdomen. The supplement’s soothing action helps alleviate feelings of fullness, bloating, and discomfort often experienced with this condition.
The compounds in DGL support the healing of peptic ulcers, including both stomach and duodenal ulcers. Clinical studies have shown that DGL can be effective as some conventional acid-reducing medications in promoting ulcer healing. DGL’s mechanism of strengthening the mucosal layer protects the ulcers from further irritation by stomach acid, allowing the tissue to regenerate. Additionally, DGL has demonstrated activity against Helicobacter pylori, a bacterium associated with the development of ulcers and gastritis.
For those experiencing symptoms of gastroesophageal reflux disease (GERD) or heartburn, DGL provides a soothing effect on the inflamed esophageal lining. By boosting the integrity of the mucosa, DGL helps shield the esophagus from the splash-back of stomach contents. DGL’s anti-inflammatory properties contribute to reducing irritation and discomfort throughout the upper digestive tract.
Practical Considerations for Use
DGL is available in several forms, but chewable tablets or lozenges are recommended for optimal effect. When DGL is chewed, it mixes with saliva, which is believed to activate its beneficial compounds before they reach the stomach. This contact with the upper digestive tract lining is important for maximizing its mucosal protective effects.
For best results in digestive support, DGL is taken about 20 minutes before meals. A common adult dosage is 380 milligrams to 1,520 milligrams, taken up to three times per day. Since the glycyrrhizin has been removed, DGL carries a low risk of the side effects associated with whole licorice, making it safe for long-term use. However, individuals should consult a healthcare provider before starting DGL, especially if they are taking other medications.