What Does Breast Cancer Look Like on a Mammogram?

A mammogram is a specialized X-ray used as a screening tool to detect signs of breast cancer before symptoms are noticeable. These images capture the internal structure of the breast, which is composed of fatty and fibroglandular tissue. Interpreting these images requires specialized training to differentiate between normal anatomical variations and subtle signs of disease. Radiologists look for specific visual characteristics, ranging from defined masses to microscopic deposits, that may indicate cancerous growth.

How Radiologists Interpret the Images

Radiologists rely on a standardized framework to read and report mammogram findings. This framework includes assessing breast density, categorized using the American College of Radiology (ACR) system. Density levels range from category A (almost entirely fatty) to category D (extremely dense); higher density can potentially obscure small masses. Comparison with previous imaging studies is crucial, as stability over time often suggests a benign process. The final assessment is communicated using the Breast Imaging Reporting and Data System (BI-RADS), which assigns a score from 0 to 6 to indicate the degree of suspicion.

Identifying Suspicious Masses and Lumps

A “mass” is a space-occupying lesion seen on at least two different mammographic projections. Suspicious masses often display an irregular shape or have spiculated margins that look like sharp lines radiating outward. Conversely, a round or oval shape with smooth, circumscribed margins is typically associated with benign findings, such as cysts or fibroadenomas. Ill-defined or indistinct margins suggest the lesion may be infiltrating the surrounding tissue, a common feature of malignancy. Masses that appear significantly whiter and denser than the surrounding tissue are generally considered more concerning, often requiring further evaluation with an ultrasound.

The Significance of Microcalcifications

Calcifications are tiny deposits of calcium that appear as bright white spots on a mammogram. Macrocalcifications are larger, coarser deposits that are almost always benign and require no further action. Microcalcifications are minute, dust-like specks that can be an early sign of breast cancer, particularly Ductal Carcinoma In Situ (DCIS). The pattern and distribution of microcalcifications are more telling than their mere presence. Suspicious microcalcifications often appear in tight clusters or have a fine linear or branching pattern, suggesting formation within the ducts. A cluster of calcifications with these specific shapes and patterns is a strong indicator for further investigation.

Subtle Signs Asymmetry and Architectural Distortion

Radiologists also look for subtle indicators suggesting changes in breast tissue beyond defined masses and calcification clusters. Asymmetry refers to an area of tissue that looks denser than the corresponding area in the opposite breast. A focal asymmetry is visible on two views but lacks defined borders; if new or enlarging, it warrants further workup. Architectural distortion is a highly concerning sign where the normal pattern of breast tissue is pulled inward without a clear, central mass. This finding is characterized by fine lines radiating from a point, indicating the tissue structure is being disrupted. Architectural distortion is frequently associated with malignancy, often leading to a recommendation for biopsy.