What Causes an Enlarged Womb?

An enlarged womb, or bulky uterus, refers to a uterus that exceeds its normal size and weight when not pregnant. A typical, non-pregnant uterus measures about 7 to 8 centimeters in length and weighs between 50 and 60 grams. It is generally considered enlarged when it exceeds approximately 10 centimeters or 100 grams. While pregnancy is the most common cause of temporary size increase, several other conditions can cause the uterus to expand significantly.

Physiological Changes

The most dramatic cause of uterine enlargement is pregnancy. Over nine months, the uterus expands significantly to accommodate a full-term fetus, increasing its volume by approximately 20 times. This growth involves both the stretching of existing muscle cells and the creation of new tissue.

Following childbirth, the uterus begins shrinking, a process known as involution. This recovery involves muscle fibers contracting strongly to compress blood vessels and reduce the organ’s size. The uterus typically returns to its pre-pregnancy size and weight within six weeks postpartum.

Uterine Fibroids

Uterine fibroids, also known as leiomyomas, are the most frequent cause of non-cancerous uterine enlargement. These are benign tumors composed of smooth muscle and fibrous tissue that develop in or on the uterine walls. Fibroids are common, affecting up to 70% of women by age 50. Their growth is strongly linked to hormones, especially estrogen and progesterone, causing them to develop during reproductive years and often shrink after menopause.

Types of Fibroids

Fibroids are classified by their location within the uterus, which determines how they affect overall size. Intramural fibroids grow within the muscular wall and are the most common type, causing the uterine structure to thicken and expand.

Subserosal fibroids develop on the outer surface, potentially growing large and making the uterus appear bigger externally. Submucosal fibroids grow just beneath the inner lining and project into the uterine cavity. While often smaller, submucosal fibroids can cause significant symptoms like heavy bleeding. All types, when numerous or large, dramatically increase the uterus’s total volume and weight.

Adenomyosis

Adenomyosis is characterized by the diffuse thickening of the uterine wall. This condition occurs when the endometrium, the tissue lining the inside of the uterus, grows inward into the muscular wall (myometrium). This misplaced tissue remains functional, thickening and bleeding with each menstrual cycle while trapped within the muscle.

The presence of this tissue triggers an inflammatory response in the surrounding myometrial cells. The result is a uniformly enlarged, bulky, and often tender uterus, sometimes doubling or tripling its typical size. Unlike fibroids, which are discrete masses, adenomyosis causes a global, symmetrical enlargement of the entire organ.

Adenomyosis is distinct from endometriosis, where endometrial-like tissue grows outside the uterus. In adenomyosis, the pathology is confined to the uterine wall itself, making the organ more massive. Estrogen exposure promotes the activity of the misplaced cells, contributing to the condition’s bulk.

Malignant Conditions

Malignant conditions involving uncontrolled cell growth can also lead to an enlarged uterus, though they are less common than benign causes like fibroids. These cancerous growths rapidly increase the size and volume of the organ. The two primary types of uterine malignancy are endometrial cancer and uterine sarcoma.

Endometrial cancer is the most common form of uterine cancer, originating in the endometrium (inner lining). This cancer begins when cells multiply rapidly and uncontrollably, forming a tumor mass. The accumulation of these abnormal cells causes the uterus to expand beyond its normal boundaries.

Uterine sarcoma is a rarer, often more aggressive cancer that arises from the muscle layer (myometrium) or supportive connective tissues. The rapid proliferation of these malignant cells forms a substantial mass within the uterine wall, leading to palpable enlargement. In both cancer types, the enlargement is a consequence of the tumor’s expanding physical presence, often accompanied by symptoms like abnormal vaginal bleeding or pelvic pressure.