What Can Mimic a UTI in a Man?

A true bacterial bladder infection (UTI) is relatively uncommon in men, especially those under the age of 50. Despite this low incidence, men frequently experience the telltale symptoms associated with UTIs, such as burning or pain during urination (dysuria), a persistent and strong urge to urinate, and increased urinary frequency. These uncomfortable complaints, known as lower urinary tract symptoms, are often caused by other conditions that irritate or obstruct the urinary tract or surrounding structures. Because the symptoms are nearly identical, careful medical evaluation is required to determine the correct diagnosis and treatment.

The Primary Imposter: Prostatitis

The most frequent cause of UTI-like symptoms in men is prostatitis, which is the inflammation and swelling of the prostate gland located just below the bladder. The prostate surrounds the urethra, the tube that carries urine out of the body, meaning that any swelling can directly constrict the flow of urine. This mechanical impingement is what causes many of the shared urinary symptoms, including urgency, frequency, and difficulty starting or maintaining a urine stream.

Prostatitis is categorized into several types, ranging from acute bacterial infection to chronic non-bacterial pain syndromes. Acute bacterial prostatitis is a severe, sudden infection that presents with systemic symptoms like high fever, chills, and flu-like body aches, alongside urinary pain. Chronic bacterial prostatitis involves recurring infections with less intense symptoms that persist over an extended period.

The most common form, however, is Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CPPS), which accounts for roughly 90% of all cases. CPPS causes urinary symptoms and pain without evidence of an active bacterial infection in the gland itself. Men with CPPS often report generalized pelvic discomfort, pain in the area between the scrotum and anus (perineum), and sometimes pain during or after ejaculation. This condition may involve issues like pelvic floor muscle dysfunction rather than simple infection.

Urethritis Caused by Sexually Transmitted Infections

Inflammation limited to the urethra, a condition called urethritis, can also perfectly mimic a bladder infection. Urethritis is especially common in younger, sexually active men and is frequently caused by a sexually transmitted infection (STI). The resulting inflammation irritates the urethral lining, leading directly to the burning sensation during urination.

Two of the most common bacterial culprits are Chlamydia trachomatis and Neisseria gonorrhoeae, which cause chlamydial and gonococcal urethritis, respectively. Gonococcal urethritis often produces a noticeable, copious, pus-like discharge from the penis. In contrast, infections caused by Chlamydia are categorized as Non-Gonococcal Urethritis (NGU) and may present with a thinner, mucoid, or sometimes no discharge at all.

Other pathogens, including Mycoplasma genitalium and the Herpes Simplex Virus (HSV), can also lead to urethritis, causing dysuria and sometimes discharge. Because these infections require specific antibiotic or antiviral treatments, accurate laboratory testing is necessary. The presence of discharge, itching at the tip of the penis, or pain in the testicles can help distinguish STI-related urethritis from other causes of urinary discomfort.

Non-Infectious and Structural Causes

Beyond infections and prostate issues, physical obstructions and chronic pain syndromes can also produce symptoms that feel exactly like a UTI. Urinary tract stones, which include kidney stones and bladder stones, create irritation and obstruction as they move through the narrow passages. As a stone travels down the ureter and approaches the bladder, it can cause severe, wave-like pain that sometimes radiates into the groin, along with a burning sensation during urination.

This pain is often sharper and more intense than the typical pressure associated with an infection, and the irritation can also lead to the presence of blood in the urine. The stone can also trigger a constant urge to urinate, as it rubs against the bladder wall or blocks urine flow. Another non-infectious condition is Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS), a chronic disorder involving long-term bladder pain and pressure without a known cause.

IC/BPS is characterized by pain that often worsens as the bladder fills and temporarily improves after emptying, along with severe frequency and urgency. While less common in men than women, it is frequently misdiagnosed because its symptoms overlap significantly with CPPS. Furthermore, non-infectious chemical irritation can also inflame the urethra or bladder lining. Exposure to perfumed soaps, certain spermicides, or highly acidic foods and drinks can cause temporary inflammation resulting in burning and urinary discomfort.

Understanding When Symptoms Require Medical Evaluation

Given the wide range of potential causes that mimic a UTI, self-diagnosis based on symptoms alone is unreliable and delays proper treatment. Certain symptoms serve as clear warnings that immediate medical attention is necessary to prevent severe complications. The presence of a high fever and chills, especially when combined with pain in the side or back below the ribs, may indicate the infection has spread to the kidneys, a serious condition called pyelonephritis.

Another red flag is the inability to urinate at all, which can signal a dangerous blockage requiring urgent intervention. Any instance of visible blood in the urine (hematuria) must be evaluated promptly, as it can be a symptom of stones, an enlarged prostate, or, less commonly, a tumor. A professional diagnosis through urine cultures and other tests is necessary to accurately identify the specific cause, whether it is a bacterial infection, prostate issue, STI, or structural problem.