What Are the Signs That Your Body Is Rejecting Hernia Mesh?

Hernia mesh is a medical device implanted during surgery to provide structural support to weakened muscle tissue and prevent hernia recurrence. This prosthetic material, often made from synthetic polymers, acts as a scaffold that encourages the patient’s own tissue to reinforce the repair site. While the procedure is common and effective, some patients experience significant adverse events. Medically, the body’s reaction is typically classified as a severe foreign body reaction, chronic inflammation, or infection, rather than true immunological rejection. These complications manifest through symptoms signaling the body is not tolerating the mesh material.

Identifying Acute and Early Adverse Signs

Adverse signs appearing shortly after surgery (within days or weeks) often indicate an acute problem, such as a surgical site infection or strong inflammatory response. The most immediate sign is severe, unrelenting localized pain that exceeds the expected discomfort of recovery. This pain may be accompanied by increased swelling, redness, or abnormal warmth radiating from the incision.

A fever or chills can signal a systemic infection where bacteria have colonized the mesh, requiring prompt medical attention. The surgical wound itself may also exhibit persistent or unusual drainage, ranging from cloudy fluid to pus.

Recognizing Chronic and Systemic Reactions

Symptoms developing months or years after surgery signal chronic complications, which are often subtle. Persistent, deep pain radiating from the repair site is common, frequently resulting from nerve entrapment by scar tissue or the mesh itself.

Chronic Local Reactions

Patients may notice a palpable lump, firmness, or stiffness caused by a seroma or dense scar tissue encapsulating the mesh. The mesh can also migrate from its original position or contract in size, leading to new pain or complications like bowel obstruction.

Systemic Reactions

In rare cases, the mesh can erode into adjacent organs, potentially creating a fistula, which is an abnormal connection between two organs or between an organ and the skin. Additionally, a growing number of patients report systemic symptoms, sometimes called Mesh Implant Illness. These include unexplained chronic fatigue, generalized joint pain, or flu-like symptoms that wax and wane over time. These widespread reactions suggest a complex, low-grade inflammatory or autoimmune-like response to the synthetic material.

Medical Confirmation and Diagnostic Steps

Confirming the mesh is the source of symptoms requires a focused clinical investigation by a specialist. Diagnosis begins with a detailed physical examination to check for tenderness, nerve pain patterns, and masses or fluid collections. Laboratory blood tests look for objective markers of inflammation or infection, such as an elevated white blood cell count or high C-reactive protein levels.

Imaging studies are essential for visualizing the mesh and surrounding structures. Ultrasound identifies fluid collections like seromas or assesses mesh integrity and location. Computed tomography (CT) scans and magnetic resonance imaging (MRI) provide a detailed view, helping detect migration, erosion into the bowel, or scar tissue formation.

Treatment Approaches for Mesh Complications

Once a mesh-related complication is confirmed, treatment is tailored to the issue’s severity and nature. For less severe chronic inflammation or nerve pain, non-surgical management is the first step, involving specialized pain medications, anti-inflammatory drugs, or targeted nerve blocks. Localized infections require a course of antibiotics, sometimes prolonged, to eradicate bacteria from the mesh surface.

When conservative measures fail, or in cases of severe complications like bowel perforation, fistula formation, or intractable pain, surgical mesh removal (explantation) is necessary. This procedure is technically demanding because tissue growth into the mesh requires meticulous dissection to avoid damaging surrounding nerves and organs.