What Are the Side Effects of Phototherapy in Newborns?

Newborn jaundice is a common condition where a baby’s skin and eyes appear yellow, typically observed in about 60% of full-term infants and 80% of preterm infants within their first week of life. This yellow discoloration stems from elevated levels of bilirubin, a yellow substance produced when the body replaces old red blood cells. While often temporary and harmless, high bilirubin levels can accumulate and potentially cause brain damage, a severe complication known as kernicterus. Phototherapy, often referred to as “bili lights,” is a widely used treatment that exposes the baby’s skin to a special light, usually blue, which helps break down bilirubin into a form the body can more easily excrete through urine and stools.

Common and Expected Reactions

During phototherapy, babies may experience several common and usually temporary reactions. A mild skin rash can develop on the baby’s skin. This rash typically resolves once phototherapy concludes.

Infants undergoing phototherapy often have loose, frequent, and sometimes greenish bowel movements. This is a normal response as the body eliminates the broken-down bilirubin.

Some infants may develop a temporary grayish-brown discoloration of the skin, mucous membranes, and urine, known as “bronze baby syndrome.” This is generally harmless, with the pigmentation gradually fading after phototherapy stops.

Increased water loss can also occur during phototherapy, potentially leading to mild dehydration, especially in premature infants. Frequent feeding, 8 to 12 times daily, is recommended to help prevent dehydration and aid in bilirubin excretion.

Less Common or More Serious Concerns

While phototherapy is generally considered safe, some less common or more serious concerns can arise. Temperature instability, such as overheating or low body temperature, can occur. Close monitoring of the baby’s temperature is therefore important.

Protecting the baby’s eyes during phototherapy is standard practice to prevent potential retinal damage. Eye covers are used as a precautionary measure, as prolonged exposure to blue light can harm the retina.

Electrolyte imbalances, such as low calcium levels, have been observed in some neonates undergoing phototherapy, particularly premature infants.

Theoretical concerns about DNA damage have also been raised, as the blue light used in phototherapy is close to ultraviolet light. While some studies suggest phototherapy may cause DNA damage, current medical understanding indicates that serious long-term effects like an increased risk of cancer are not clinically evident for most newborns. However, ongoing research continues to explore these possibilities.

Monitoring and When to Seek Medical Attention

During and after phototherapy, careful monitoring of the newborn is important. Healthcare providers typically monitor vital signs and temperature at least every four hours, and more frequently if needed. The baby’s bilirubin levels are also tested regularly, often every 4 to 6 hours after phototherapy begins, to assess the treatment’s effectiveness.

Parents and caregivers should observe for changes in the baby’s activity level, such as excessive sleepiness, or alterations in feeding patterns, including poor feeding or weight loss. The number of wet and dirty diapers should also be tracked, as decreased output can indicate dehydration.

It is important to contact a healthcare provider if there are signs of significant dehydration, such as reduced urination, or if the baby develops a persistent fever. Unusual skin changes beyond mild rashes, or if the baby appears generally unwell, also warrant immediate medical attention. Following medical advice regarding feeding schedules and phototherapy duration is important for the baby’s well-being.

Long-Term Considerations

For the majority of newborns, phototherapy is a safe and effective treatment for jaundice with no known significant long-term adverse effects when administered appropriately. Decades of use have not resulted in clinical evidence of irreversible or serious complications. Growth, including head circumference, is generally not affected by the treatment.

While some studies have explored potential links to conditions like allergic diseases or certain skin changes, these findings often require further validation. The consensus remains that the benefits of preventing severe hyperbilirubinemia and its potential for brain damage significantly outweigh the minor and largely temporary side effects of phototherapy. Ongoing research continues to refine understanding and optimize treatment protocols to minimize any potential risks.

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