Biostimulator injections represent an innovative approach in aesthetic medicine, designed to rejuvenate the skin by stimulating its natural regenerative capabilities. These injectable treatments fundamentally differ from traditional dermal fillers, which primarily add immediate volume to specific areas. Instead, biostimulators work to encourage the body’s own production of vital structural components like collagen and elastin, leading to gradual and natural-looking improvements in skin quality and structure.
How They Work
Biostimulator injections operate by introducing biocompatible substances into the deeper layers of the skin, typically the dermis. This introduction triggers a controlled biological response within the body, activating specialized cells called fibroblasts. Fibroblasts are responsible for synthesizing new collagen, a protein providing structural support and firmness, and elastin, which contributes to the skin’s flexibility and resilience. As these natural proteins are gradually produced over time, they reinforce the skin’s underlying foundation, leading to improved texture, elasticity, and overall skin quality. This process results in a subtle and progressive rejuvenation rather than an instant, dramatic change.
Common Applications
Biostimulator injections are widely used to address various signs of aging and improve skin quality across different body areas. On the face, they are frequently applied to restore lost volume in the cheeks, temples, and jawline, helping to redefine facial contours. They also effectively reduce the appearance of fine lines, wrinkles, and folds, such as nasolabial folds and marionette lines. Beyond the face, biostimulators can enhance the neck and décolletage by improving crepey skin and laxity. Other common treatment areas include the hands to restore lost volume, and certain body areas like the knees, elbows, abdomen, and buttocks for skin tightening and contour improvement.
Key Types of Biostimulators
Several types of biostimulators are available, each utilizing different materials to stimulate collagen production.
Poly-L-lactic Acid (PLLA) is a biocompatible and biodegradable synthetic polymer, often derived from lactic acid. When injected, PLLA microparticles, typically having an irregular, microflake-like shape, stimulate an immune response that attracts fibroblasts to produce new collagen. Results develop gradually over several months and typically last up to two years or more.
Calcium Hydroxylapatite (CaHA) is another common biostimulator. It is composed of smooth, spherical microspheres suspended in a gel carrier. CaHA is a natural component found in bone and is biocompatible and biodegradable. The gel provides some immediate volume, while the microspheres create a scaffold that stimulates collagen and elastin production. Effects can last between 12 to 18 months, or up to two years.
Poly-DL-lactic Acid (PDLLA) represents a newer generation of biostimulators. This substance is FDA-approved, biocompatible, and biodegradable, working to naturally stimulate the body’s collagen production. Like other biostimulators, PDLLA aims to restore natural volume and improve skin quality over time, with results extending up to two years.
What to Expect from Treatment
The biostimulator treatment process begins with a consultation where a healthcare provider assesses the skin and discusses aesthetic goals. During the procedure, the selected biostimulator is precisely injected into targeted areas using a fine needle or cannula. Numbing cream or lidocaine is often used for comfort, and the injection session usually takes between 30 to 60 minutes.
Following treatment, patients may experience mild swelling, bruising, or redness at the injection sites, which generally subside within a few days. Post-treatment care instructions, such as gentle massage for certain biostimulators, are recommended. Patients are advised to avoid strenuous activity for a few days. Improvements become noticeable within a few weeks, with full effects appearing over three to six months as new collagen develops. Multiple treatment sessions, spaced several weeks apart, are commonly recommended to achieve lasting results, often enduring for two years or more.