Yes, there is a new Pfizer COVID vaccine. The most recent version, called Comirnaty (2024-2025 Formula), was approved by the FDA on August 22, 2024, and targets the KP.2 Omicron subvariant. An even newer formula for fall 2025 is already in the works, with the FDA advising manufacturers to target the LP.8.1 strain from the JN.1 lineage.
What the Current Vaccine Targets
The 2024-2025 Pfizer vaccine is a monovalent formula designed around the KP.2 Omicron subvariant. In studies published in The Lancet Infectious Diseases, the updated shot produced strong neutralizing antibody responses against several circulating variants one month after vaccination. Antibody levels were highest against JN.1, with measurable responses against KP.3, KP.3.1.1, and XEC as well. Compared to pre-vaccination levels, a greater proportion of people generated neutralizing antibodies against these newer subvariants.
For fall 2025, the FDA has directed vaccine makers to shift their target again. The next round of COVID vaccines should use the LP.8.1 strain, which belongs to the JN.1 lineage and more closely matches what’s circulating now. Pfizer’s 2025-2026 Comirnaty vaccine will be approved for anyone ages 5 and older.
Who Should Get It
The CDC recommends the 2025-2026 COVID vaccine for everyone ages 6 months and older, based on individual decision-making. That recommendation applies whether you’ve been vaccinated before, have had COVID, or are dealing with long COVID. If you recently had COVID, you can delay getting vaccinated for three months after your symptoms started or after a positive test.
One important change for parents of young children: Pfizer is no longer authorized for kids ages 6 months through 4 years. Only Moderna’s Spikevax vaccine is approved for that age group. Pfizer’s Comirnaty picks up at age 5 and older.
What to Expect for Side Effects
The side effect profile for the updated vaccines remains consistent with earlier versions. At the injection site, you may notice redness, soreness, or swelling. More general reactions include fatigue, headache, muscle aches, joint pain, chills, and mild fever. These typically resolve within a day or two and are signs your immune system is responding to the vaccine.
Getting It With Your Flu Shot
You can get a COVID vaccine and a flu vaccine at the same visit with no required waiting period between them. Studies support the safety of this approach. If both are given as injections, they should be placed at least one inch apart, either in the same arm or in different arms. If you’re also eligible for an RSV vaccine, all three can be given during a single appointment.
Cost and Where to Find It
Most private insurance plans, including all Health Insurance Marketplace plans, must cover recommended vaccines at no cost to you when you use an in-network provider. That applies even if you haven’t met your yearly deductible. For uninsured individuals, some vaccine supply is available through state health department immunization programs, though availability is more limited than in prior years. If you don’t have insurance, HealthCare.gov lists affordable coverage options.