Nebivolol, commonly prescribed under the brand name Bystolic, is a medication used to manage cardiovascular conditions. For many years, patients relied solely on the brand-name product, which often resulted in high out-of-pocket costs. Consumers frequently ask whether a more affordable, generic version of this popular prescription is available, and the status of Nebivolol’s generic availability is now clear.
What is Nebivolol Used For?
Nebivolol is classified as a selective beta-1 adrenergic blocker, meaning it primarily targets specific receptors in the heart. By blocking these receptors, the medication decreases the effects of stress hormones, causing the heart to beat more slowly and with less force. This action effectively reduces the heart’s workload and lowers blood pressure.
The drug has a unique dual mechanism of action, distinguishing it from older beta-blockers. In addition to its primary effect on the heart, Nebivolol also stimulates the production of nitric oxide in the blood vessel lining. This secondary action promotes vasodilation, the relaxation and widening of blood vessels, contributing further to lower blood pressure and improved blood flow. Nebivolol is primarily indicated for treating hypertension and may be used alone or in combination with other agents.
Generic Availability and Name
A generic version of the brand-name drug Bystolic is available for prescription. The generic name for Bystolic is simply nebivolol, which is the identical active ingredient found in the brand formulation. This shift occurred after the brand manufacturer’s patents expired, allowing other companies to produce the medication.
The generic version is available as nebivolol tablets in the same common dosage strengths as the brand-name product, including 2.5 mg, 5 mg, 10 mg, and 20 mg. Generic manufacturers must undergo a rigorous process with the U.S. Food and Drug Administration (FDA) by submitting an Abbreviated New Drug Application (ANDA). This application confirms that the generic product is bioequivalent to the brand-name drug, meaning it works in the same way and at the same rate.
The FDA granted initial approvals for generic nebivolol to various manufacturers starting around the mid-2010s, with significant commercial market entry occurring around 2021 and 2022. This regulatory milestone ensures that generic nebivolol provides the same therapeutic benefit as Bystolic. Multiple pharmaceutical companies now manufacture the generic tablets, which helps ensure a steady supply and promotes market competition.
Navigating Costs and Alternatives
The availability of generic nebivolol has resulted in substantial cost savings for patients managing high blood pressure. Brand-name Bystolic can cost upward of $200 for a typical 30-day supply without insurance coverage. In contrast, generic nebivolol can often be obtained for as little as $10 to $20 for the same quantity, depending on the pharmacy and discount programs used.
Patients should speak with their prescribing physician and pharmacist to ensure the generic version is dispensed, as state laws and individual insurance plans may vary. Patients can request that their doctor write the prescription for “nebivolol” rather than “Bystolic” to facilitate the switch. Pharmacists can also check for money-saving options like prescription discount cards, which often lower the price of generic medications.
If the cost of generic nebivolol remains a concern, or if a patient experiences side effects, they should discuss alternative beta-blockers with their healthcare provider. Older beta-blockers, such as metoprolol or atenolol, have been generic for a long time and may be less expensive. Any potential change in medication, however, should be a collaborative decision between the patient and their physician to ensure the new drug is medically appropriate.