Is It Normal for an IV to Hurt? Causes & When to Alert a Nurse

It is common to have questions about discomfort during intravenous (IV) therapy, and understanding what sensations are typical can help reduce anxiety. While some temporary discomfort is expected, persistent or severe pain is not a normal part of the process. Knowing the difference between usual sensations and those that warrant attention can empower individuals to communicate effectively with their healthcare providers.

Expected Sensations During IV Insertion

During the initial placement of an IV, a brief, sharp pinch or sting is commonly felt as the needle penetrates the skin. This sensation is typically fleeting and subsides quickly once the needle has entered the vein. After the needle is removed, a small, flexible plastic tube, known as a cannula, remains in the vein to deliver fluids or medications.

Once the cannula is secured within the vein, the discomfort usually transitions to a dull pressure or fullness at the site. This feeling is generally mild and should not be painful. The goal of IV placement is to ensure the catheter is positioned correctly and comfortably for the duration of the therapy.

Reasons for Ongoing IV Discomfort

If an IV site continues to hurt beyond the initial insertion, various factors could be at play. One common reason for persistent discomfort is vein irritation, which can occur if the catheter rubs against the inner wall of the vein or if the vein selected is too small for the catheter size. This mechanical irritation can lead to inflammation.

Certain medications or solutions infused through the IV can also cause irritation, leading to burning or stinging sensations. Solutions with high osmolarity or extreme pH levels, such as some antibiotics, potassium, or chemotherapy drugs, are known to be more irritating to the vein lining. Rapid infusion of these substances can intensify the discomfort.

Infiltration, another cause of pain, happens when IV fluid or medication leaks out of the vein and into the surrounding tissue. This leakage causes swelling, tightness, and a cool sensation at the IV site. Extravasation, a more severe form, occurs when irritating medication leaks into tissue, potentially causing significant pain, blistering, or tissue damage.

Phlebitis, inflammation of the vein, can also cause ongoing pain. It presents with tenderness, redness, warmth, and sometimes a cord-like feeling along the affected vein. Phlebitis can stem from mechanical or chemical irritation, or infection. Movement or accidental bumping of the IV site can also cause localized discomfort.

When to Alert Your Healthcare Provider

Inform your healthcare provider of any worsening or new pain at your IV site after initial insertion. Any severe or unbearable increase in pain warrants immediate attention.

New or worsening swelling, redness, or warmth around the IV site could indicate infiltration or phlebitis. A cool or numb sensation may suggest compromised circulation. Wetness or leaking from the insertion point indicates the IV may not be properly seated.

Report persistent burning or stinging, especially if it intensifies during infusion. Fever or chills with IV site discomfort could signal infection. Always communicate these concerns to your nurse or doctor for assessment, adjustments, or reinsertion. Do not attempt to adjust the IV yourself.

What Is Included in an 8-Panel Drug Test?

What Happens If I Don’t Use Distilled Water in My CPAP?

What Are the Risks of Taking Morphine and Adderall?