Is Hydroxyzine a Narcotic or a Controlled Substance?

This article clarifies whether hydroxyzine is a narcotic or controlled substance, addressing common questions about its properties and legal standing. Understanding a medication’s classification is important for safe and informed use.

Understanding Hydroxyzine

Hydroxyzine is a first-generation antihistamine, primarily acting as a histamine H1-receptor antagonist. It works by blocking histamine, a natural substance in the body that can cause allergic symptoms. It also exhibits sedative and anxiolytic effects.

Healthcare professionals prescribe hydroxyzine for anxiety and tension, and to treat itching (pruritus) associated with allergic reactions. It can also serve as a sedative before and after general anesthesia. Effects typically appear within 15 to 60 minutes and last four to six hours.

Distinguishing Hydroxyzine from Narcotics

Hydroxyzine is not a narcotic, nor is it classified as a controlled substance. Narcotics are generally defined as opioid-based drugs that dull the senses, relieve pain, and can induce profound sleep. These substances, derived from opium or synthetic substitutes, carry a high potential for abuse, addiction, and dependence, which is why they are subject to strict government regulation under controlled substance schedules.

Hydroxyzine does not fit this definition. It is an antihistamine that influences the central nervous system, leading to its anxiolytic and sedative effects. Unlike narcotics, hydroxyzine does not activate opioid receptors in the brain, nor does it possess the same high potential for abuse or addiction. Its mechanism of action involves blocking histamine and affecting certain other receptors, which differs fundamentally from how opioid narcotics function.

The sedative properties of hydroxyzine can sometimes lead to the misconception that it is a narcotic or controlled substance. However, despite its ability to induce drowsiness and reduce anxiety, it is not listed in the Controlled Substances Act. This distinction highlights its lower risk profile for dependence and abuse compared to controlled substances like opioids or benzodiazepines.

Safety and Usage Considerations

While hydroxyzine is not a controlled substance, its use requires careful consideration and professional medical guidance. Common side effects can include drowsiness, dry mouth, and headache. Some individuals may also experience dizziness or confusion.

It is important to use hydroxyzine exactly as prescribed by a healthcare professional. Driving or operating machinery should be avoided until an individual understands how the medication affects them, as it can impair mental alertness and coordination. Combining hydroxyzine with alcohol or other central nervous system depressants, such as opioids or certain sleep medications, can significantly increase sedative effects and lead to serious adverse reactions, including severe drowsiness and slowed breathing.

Individuals should discuss their full medical history and all other medications, including over-the-counter drugs and supplements, with their doctor before starting hydroxyzine. This is particularly important for those with pre-existing heart conditions, as hydroxyzine can affect heart rhythm in rare cases. Hydroxyzine is typically prescribed for short-term use, and prolonged administration should be regularly re-evaluated by a healthcare provider.

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