Progesterone cream is a topical application used for managing certain symptoms associated with Polycystic Ovary Syndrome (PCOS). This cream contains progesterone, a hormone that plays a role in the female reproductive system.
Understanding Progesterone’s Role in PCOS
PCOS often involves a hormonal imbalance with lower levels of progesterone and comparatively higher levels of estrogen. Progesterone is a hormone primarily produced after ovulation by the corpus luteum, the structure left behind in the ovary after an egg is released. In PCOS, irregular or absent ovulation is common, which can lead to a deficiency in natural progesterone production.
This imbalance contributes to various PCOS symptoms, including irregular periods, mood changes, and an increased risk of uterine lining overgrowth. Progesterone cream is theorized to help by introducing exogenous progesterone, aiming to counteract the effects of relatively higher estrogen levels. Additionally, progesterone has anti-androgen effects and can influence the hypothalamus, which may help lower androgen levels and support the return of more regular ovulation.
Applying Progesterone Cream
Progesterone cream is designed for transdermal absorption, meaning it is absorbed through the skin into the bloodstream. For effective absorption, apply the cream to areas with thinner skin and good blood supply. Common application sites include the inner arms, upper chest, lower back, inner thighs, and behind the knees. Rotating the application site daily can help prevent skin irritation and potentially improve absorption. Some sources also suggest applying the cream above the navel to avoid rapid metabolism by the liver.
Dosage and frequency vary, but cyclical application is common to mimic natural hormone rhythms. For instance, some guidance suggests applying the cream daily for 10 to 12 days in the second half of the menstrual cycle, often starting around day 16 (16 days after the start of a period) and then stopping. For those with irregular periods, a “two weeks on, two weeks off” schedule might be suggested until cycles become more regular. A common daily dose might range from 20 to 75 milligrams, or about 1/4 teaspoon (a dime-sized dollop), applied once or twice daily. Apply the cream to clean, dry skin, avoiding lotions or oils that could hinder absorption.
Potential Effects and Precautions
Progesterone cream is used for PCOS symptoms, but potential effects and necessary precautions exist. Side effects can include tiredness, weakness, breast tenderness, and changes in menstrual cycles. Some individuals may experience headaches, nausea, bloating, or mood shifts such as anxiety or depression. Rarely, more serious effects like changes in vision, dizziness, or allergic reactions such as skin rash or difficulty breathing can occur.
Progesterone is fat-soluble and can accumulate in fatty tissues with long-term use, which might lead to higher-than-desired levels. Avoid applying the cream to broken or irritated skin and keep it away from sensitive areas like the eyes and mouth. Individuals with certain pre-existing conditions, such as liver or kidney problems, a history of hormone-related cancers, or bleeding disorders, should exercise caution or avoid using progesterone cream. Over-the-counter progesterone creams are generally not FDA regulated, meaning the exact amount absorbed can be inconsistent.
Important Considerations for Use
Consulting with a healthcare professional is important before starting progesterone cream for PCOS. A medical professional can provide a proper diagnosis of PCOS and assess individual hormone levels through testing. This helps determine if progesterone cream is an appropriate option and what dosage and application schedule would be suitable.
Ongoing monitoring by a healthcare provider is recommended to track symptoms, evaluate the cream’s effects, and adjust the dosage as needed. Progesterone cream is not a universal solution for PCOS, and its effectiveness varies. Relying on professional guidance ensures that its use is integrated into a comprehensive treatment plan, considering other lifestyle factors and potential co-existing conditions.