Progesterone cream is a topical supplement containing progesterone, a hormone naturally produced in the body, primarily in the ovaries. This cream is absorbed through the skin, aiming to supplement the body’s progesterone levels. It is often used by individuals experiencing symptoms associated with hormonal imbalances, particularly those related to fluctuating or declining progesterone.
Understanding Your Progesterone Cream Product
Over-the-counter progesterone creams typically contain bioidentical progesterone, which is chemically identical to the hormone the human body produces. These are often derived from plant sources like wild yam or soy, though the human body cannot convert wild yam extract directly into progesterone without laboratory processing. Synthetic forms, called progestins, are chemically modified and may act differently in the body.
Always check the product’s concentration, often listed as milligrams per pump or dose, as this varies significantly between brands. Store the cream as directed by the manufacturer, typically in a cool, dark place, and check the expiration date. Over-the-counter progesterone creams are not regulated by the FDA’s drug division, so the exact amount of progesterone absorbed can vary. Adhere to the product’s specific instructions.
Detailed Application Instructions
Applying progesterone cream effectively involves specific steps. A typical starting dose for topical progesterone is around 20-40 mg, applied once or twice daily. This often translates to approximately a quarter to a half teaspoon, or one to two grams of cream, depending on the product’s concentration.
Select areas of the body where the skin is thinner for application, as this can enhance absorption. Common sites include the inner wrists, inner arms, neck, inner thighs, chest, or abdomen. Some sources suggest applying the cream above the navel to avoid rapid metabolism by the liver.
To prevent saturation of receptor sites and potential skin irritation, rotate application sites with each use. For instance, if applied to the right inner arm in the morning, choose the left inner arm or another thin-skinned area for the evening application. Always ensure hands are clean before and after applying the cream.
The frequency of application varies based on individual needs. For those with regular menstrual cycles, application might begin after menstruation and continue for a specific duration, such as days 12 through 25 of the cycle. Individuals with irregular periods or those using estrogen supplementation may follow a different schedule, sometimes applying the cream daily or twice a day.
Monitoring for Effects and Side Effects
After beginning progesterone cream, individuals may notice changes in their body’s response. The timeline for observing these effects can vary; some users report noticing effects within the first menstrual cycle, while for others, it may take two to three months of consistent use. Individual responses differ, and not everyone will experience the same improvements.
Track any changes in symptoms, such as improvements in mood, sleep quality, or the reduction of hot flashes. Be aware of potential side effects. Common, mild reactions can include headaches, dizziness, nausea, fatigue, breast tenderness, bloating, changes in menstrual cycles, or localized skin irritation at the application site.
These common side effects are often temporary and may subside as the body adjusts to the hormone. Keep a record of any symptoms experienced, noting their severity and duration, to discuss with a healthcare provider if concerns arise.
Important Considerations and When to Consult a Doctor
Using progesterone cream requires careful consideration. Avoid applying the cream to sensitive areas, such as mucous membranes, or to broken or irritated skin, as this can cause discomfort or affect absorption. While generally well-tolerated, some individuals may experience skin irritation, especially if applied repeatedly to the same area.
Progesterone can interact with other medications, including blood thinners and certain hormone therapies. Discuss all current medications and supplements with a healthcare provider before starting progesterone cream to identify any potential interactions. Progesterone may also cause drowsiness in some individuals, so caution is advised when driving or operating machinery, particularly when first starting use.
Consult a healthcare provider before beginning any hormone therapy, including over-the-counter progesterone cream. This is especially true if you are pregnant or nursing, have a history of hormone-sensitive conditions like certain cancers, blood clots, liver dysfunction, or undiagnosed vaginal bleeding. Seek immediate medical attention for severe or persistent side effects, such as:
Allergic reactions (hives, swelling, difficulty breathing)
Sudden severe headaches or vision changes
Signs of blood clots (leg pain or swelling, chest pain, shortness of breath)
No improvement in symptoms after a reasonable period