Mesalamine suppositories deliver medication directly to the rectum and lower colon to reduce inflammation. This targeted approach helps address localized symptoms within the gastrointestinal tract.
Before You Use Your Suppository
Before administering a mesalamine suppository, review the specific instructions provided with your medication. Thoroughly wash your hands with soap and water to ensure cleanliness. Find a comfortable, private position, such as lying on your side with one leg extended and the other bent. Having a bowel movement just before using the suppository can help the medication work more effectively, allowing it to remain in place longer.
Step-by-Step Application Guide
Begin by carefully unwrapping the suppository. Handle it as little as possible, as body heat can cause it to melt. If too soft, hold it under cold water while still in its wrapper or place it in the refrigerator for a few minutes to firm it up. For easier insertion, apply a small amount of water-based lubricating gel to the tip; avoid petroleum jelly.
Once prepared, gently insert the suppository, pointed end first, into the rectum using your finger. Apply gentle pressure to guide it completely past the anal sphincter, which is the muscular opening of the rectum. For adults, inserting it about one to three inches typically ensures it remains in place and dissolves properly. After insertion, hold your buttocks together for a few seconds to help keep the suppository in place.
After Application and Storage
After inserting the suppository, remain lying down for a few minutes to allow the medication to dissolve and absorb. Avoid a bowel movement for at least one to three hours, or longer if advised by your doctor, to give the medicine time to work effectively. If a suppository comes out within 10 minutes, you may insert another. Wash your hands again with soap and water after application.
Proper storage of mesalamine suppositories helps maintain their effectiveness. Store them below 25°C (77°F) or refrigerate; do not freeze. Keep the medication away from direct heat, light, and humidity, and ensure the container is tightly closed. Store all medications out of the reach of children and pets. Mesalamine can stain surfaces like clothing, flooring, and countertops, so exercise caution during handling.
Important Considerations and When to Contact Your Doctor
Maintain adequate fluid intake while using mesalamine suppositories to help prevent kidney stones. If you miss a dose, administer it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular schedule; never double doses. Mesalamine suppositories are for rectal use only; do not take by mouth, cut, or break unless instructed by your healthcare provider.
Contact your doctor immediately if you experience severe abdominal pain, cramping, or bloody diarrhea. Seek medical attention if you develop signs of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. Other concerning symptoms include chest pain, difficulty breathing, fever, headache, rash, or any changes in urination, such as increased or decreased output, or blood in the urine, as these may signal kidney problems.