Nattokinase is an enzyme that originates from natto, a traditional Japanese food made by fermenting soybeans with the bacterium Bacillus subtilis. This process yields an enzyme known for its fibrinolytic activity, meaning it breaks down fibrin, a protein involved in blood clotting. Due to this function, nattokinase has gained attention as a dietary supplement for supporting circulatory health. Utilizing this supplement safely and effectively requires a clear understanding of its dosage, administration guidelines, and safety protocols.
Determining the Proper Dosage
The potency of nattokinase is not measured in standard weight units like milligrams (mg); instead, it is quantified by its functional activity using Fibrinolytic Units (FU). This unit directly reflects the enzyme’s ability to degrade fibrin in a laboratory setting, offering a more precise measure of its potential biological effect than a simple weight measurement. Different manufacturers may produce nattokinase with varying levels of enzymatic activity per milligram, making the FU designation the standard for consumers to compare products effectively.
The standard starting and maintenance dose is 2,000 FU, which typically corresponds to approximately 100 milligrams of the enzyme extract. This dosage is taken once daily and has been used in trials evaluating its effects on blood pressure and blood flow over periods of about eight weeks. Some individuals may use a higher maintenance dose, ranging from 3,000 FU to 4,000 FU daily, which often requires taking multiple capsules.
It is important to inspect the supplement facts panel on the product label, as the potency can vary widely between different brands. The label should clearly state the FU value per capsule or serving size, ensuring you are receiving the intended amount of active enzyme. Consulting a healthcare professional can help tailor the dosage to individual needs and health status.
Guidelines for Administration
Nattokinase should be taken on an empty stomach. If consumed alongside a meal, especially one high in protein, this powerful proteolytic enzyme will preferentially act as a general digestive aid. Taking the enzyme away from food ensures it is absorbed into the bloodstream for its intended systemic function.
The recommendation is to take the supplement at least 30 minutes before a meal or approximately two hours after eating. This timing allows the enzyme to pass quickly through the stomach and be absorbed through the small intestine, maximizing its systemic availability. Consistency in daily intake is also important for maintaining circulating levels of the enzyme to support long-term circulatory health.
While nattokinase is considered acid-resistant, some supplements are delivered in enteric-coated or delayed-release capsules for added protection. Choosing a high-quality formulation helps ensure the enzyme remains intact until absorption. Many people take their daily dose first thing in the morning upon waking, or in the evening before bed, to adhere to the empty stomach requirement.
Important Safety Considerations
Nattokinase requires careful consideration of potential interactions and contraindications. There is a heightened risk of bleeding, especially when combined with other medications that also slow blood clotting. Individuals currently taking prescription blood thinners, such as warfarin or antiplatelet drugs like aspirin and clopidogrel, should not take nattokinase without strict medical supervision.
Nattokinase is contraindicated for individuals with pre-existing bleeding disorders, a recent history of hemorrhagic stroke, or active peptic ulcers. It is recommended that individuals stop taking nattokinase at least two weeks before any scheduled surgical procedure, including dental surgery. The enzyme may also amplify the effects of blood pressure-lowering medications, potentially causing blood pressure to drop too low.
There is insufficient reliable information regarding the safety of nattokinase for women who are pregnant or breastfeeding, so its use should be avoided. A consultation with a healthcare provider is strongly advised before beginning supplementation, especially for anyone with a medical condition or who is currently taking prescription medication.