Diosmin and hesperidin are bioflavonoid compounds that are naturally sourced, most commonly from citrus rinds. These substances are frequently used together in supplement form, as they work synergistically to support the body’s vascular system. They are classified as phlebotonics, a group of agents that have a beneficial effect on the tone of blood vessel walls. This combined formulation is primarily used to promote healthy circulation and maintain the structural integrity of veins and capillaries, focusing on improving the way blood flows back to the heart.
Conditions Treated by Diosmin and Hesperidin
The primary application for this bioflavonoid combination is the management of Chronic Venous Insufficiency (CVI), which occurs when leg veins struggle to return blood effectively. CVI symptoms, such as the feeling of heavy, tired, or painful legs, are often relieved by this treatment. The compounds work by improving venous tone, which helps reduce the distensibility of veins and limits the pooling of blood, also known as stasis.
The combination also addresses the inflammation and reduced capillary integrity associated with CVI. It helps normalize the permeability of small blood vessels, reducing the leakage of fluid into surrounding tissues that causes swelling or edema. By improving microcirculation and enhancing lymphatic drainage, the supplement helps clear accumulated fluid and proteins from the limbs. This multifaceted action provides relief from common symptoms like nocturnal leg cramps and the sensation of restless legs.
Another major use is in the treatment of acute and chronic hemorrhoidal disease. For acute hemorrhoidal crises, the anti-inflammatory and venotonic properties help reduce symptoms like pain, bleeding, and anal discharge. By strengthening the capillary resistance in the anal cushions, the supplement helps manage the swelling and discomfort associated with both flare-ups and long-term maintenance. Using this formulation can also be an adjunctive therapy for venous leg ulcers, supporting the healing process alongside standard treatments like compression therapy.
Practical Dosage and Administration Guidance
The most commonly studied and recommended form of this supplement is the Micronized Purified Flavonoid Fraction (MPFF), which ensures better absorption by reducing particle size. This fraction typically maintains a ratio of 90% diosmin to 10% other active flavonoids, predominantly hesperidin. A standard total daily dose is often 1,000 mg, which translates to 900 mg of diosmin and 100 mg of hesperidin.
For the management of Chronic Venous Insufficiency symptoms, a typical daily intake is 1,000 mg. This can be taken as one single dose in the morning or divided into two 500 mg doses. It is specifically recommended to take the tablets with meals to maximize absorption and minimize the potential for gastrointestinal upset. Treatment for chronic conditions like CVI often lasts for several months, with clinical trials suggesting periods up to six months.
Dosage for acute hemorrhoidal crises requires a higher, short-term loading regimen to quickly manage severe symptoms. The typical recommendation is to take 3,000 mg daily for the first four days, often divided into three doses of 1,000 mg each. This is then followed by a reduced dose of 2,000 mg daily, divided into two doses, for an additional three days. Once the acute phase resolves, the dosage usually transitions to a lower maintenance dose, such as 1,000 mg once daily, for continued management over approximately three months.
Potential Side Effects and Drug Interactions
Diosmin and hesperidin are generally well-tolerated when taken at the recommended doses. The most common adverse reactions involve the digestive system, including stomach pain, diarrhea, nausea, vomiting, and dyspepsia. Some users may also experience central nervous system effects such as dizziness or a mild headache. If a rash or severe abdominal pain develops, it is prudent to consult a healthcare provider.
A notable consideration for this supplement is its potential to interact with medications that affect blood clotting. Because the bioflavonoids may slow blood clotting, taking them concurrently with anticoagulant or antiplatelet drugs could increase the risk of bruising or bleeding. Individuals taking blood thinners such as warfarin, aspirin, or clopidogrel should discuss the use of diosmin and hesperidin with their physician.
The supplement may also interact with medications metabolized by certain liver enzymes, potentially altering their effectiveness or side effects. Use during pregnancy or breastfeeding should only occur under the direct guidance of a doctor. For those planning any surgical procedure, it is generally advised to stop taking the supplement at least two weeks beforehand to reduce the risk of excessive bleeding.