Morning sickness, characterized by nausea and vomiting, is a common experience during pregnancy, affecting up to 70% of expectant mothers in the first trimester. Despite its name, these symptoms can occur at any time of day or night, significantly impacting daily life. Vitamin B6, also known as pyridoxine, is a recommended option for managing them.
How B6 Helps with Morning Sickness
Vitamin B6 helps alleviate nausea and vomiting by influencing neurotransmitters in the brain. These neurotransmitters regulate digestion and the sensation of nausea. While the exact mechanism is not fully understood, some research suggests lower levels of circulating vitamin B6 may be present in pregnant women experiencing nausea and vomiting. Supplementing with B6 may help to rebalance these pathways, reducing symptoms.
Practical Guidance for Taking B6
For managing morning sickness, vitamin B6 is typically taken as an over-the-counter supplement. A common dosage range is 10 mg to 25 mg, taken three to four times a day. This often amounts to a total daily intake between 30 mg and 75 mg. Consistency is important, and it can be beneficial to take the supplement regularly, even if symptoms are mild.
Combining B6 with Doxylamine
For persistent or severe symptoms, combining vitamin B6 with doxylamine, an antihistamine, is a recommended approach. This combination is available as prescription medications like Diclegis or Diclectin, specifically approved for nausea and vomiting of pregnancy. These prescription versions are often delayed-release, providing sustained relief.
This combination can also be created using over-the-counter products. A typical regimen involves 10 mg to 25 mg of vitamin B6 three times daily, plus 12.5 mg of doxylamine (e.g., Unisom SleepTabs) once daily, usually at bedtime. The American College of Obstetricians and Gynecologists (ACOG) suggests trying B6 alone first, then adding doxylamine if symptoms persist. This combination has been extensively studied and is supported by healthcare providers for its effectiveness and safety during pregnancy.
Important Safety and Usage Notes
Before starting any new supplement during pregnancy, consult a healthcare provider. While vitamin B6 is generally safe at recommended dosages, exceeding 200 mg per day without medical guidance is not advised. Very high doses, typically 500 mg or more daily, have been linked to potential side effects such as nerve damage. However, such adverse effects are unlikely at the dosages recommended for morning sickness.
If nausea and vomiting worsen, become severe, or are accompanied by concerning symptoms like significant weight loss, dehydration, or inability to keep down fluids for 24 hours, seek immediate medical attention. These could be signs of hyperemesis gravidarum, a severe form of pregnancy sickness requiring professional medical assessment and treatment.