Dimethyl sulfoxide (DMSO) is a distinctive organic compound with diverse applications. Discovered in the 19th century as a paper-making byproduct, it’s a colorless liquid known for dissolving both polar and nonpolar compounds, making it a versatile industrial and laboratory solvent. In the 1960s, researchers noted its ability to penetrate skin and biological membranes without damage, leading to its exploration as a substance delivery vehicle. This article provides practical guidance for the safe and effective topical application of DMSO.
Preparing for Application
Before applying DMSO to the skin, careful preparation is essential to ensure both safety and effectiveness. Selecting a high-grade DMSO is paramount; pharmaceutical or laboratory-grade options are preferable to industrial grades, which may contain impurities. DMSO is frequently diluted for topical use, with concentrations typically ranging from 10% to 90%.
When diluting concentrated DMSO, use distilled water to maintain purity. The dilution process should occur in suitable containers, such as glass or high-density polyethylene (HDPE) plastics. Thoroughly clean the skin before application to prevent the transport of unwanted substances or contaminants into the body.
A patch test is a necessary safety measure before a full application. Apply a small amount of the diluted DMSO to an inconspicuous area of skin, like the inner forearm. Observe the area for at least 24 hours to check for any adverse reactions, such as excessive redness, itching, or irritation, before proceeding with broader application.
Topical Application Methods
Applying DMSO to the skin requires specific tools and techniques. Suitable application tools include clean hands, cotton balls, or soft brushes. Avoid materials that could react with DMSO, such as certain synthetic fabrics or low-grade plastics.
When applying, spread a thin, even layer of the diluted DMSO directly onto the skin. Gentle rubbing can aid in distribution, but excessive force is unnecessary. The goal is to allow the skin to absorb the liquid without creating a thick, pooling layer.
DMSO is readily absorbed through the skin; a characteristic garlic-like odor or taste may be noticed shortly after application. After application, allow the area to air dry completely before covering it. This prevents transfer to fabrics and ensures full absorption.
General guidelines for frequency and duration suggest that topical application can vary depending on the intended purpose and individual response. Some applications may involve daily use, while others might be less frequent. Monitoring the skin’s reaction and consulting with a knowledgeable professional can help determine an appropriate regimen.
Safety Considerations and Precautions
When using DMSO topically, understanding potential reactions and precautions is important. Common side effects include localized skin irritation, itching, dryness, and a distinct garlic-like body odor or taste. These reactions are often mild but should be monitored.
More severe allergic reactions, though less common, can manifest as significant rash, hives, swelling, or difficulty breathing. If any signs of a severe allergic reaction appear, discontinue use immediately and seek urgent medical attention.
DMSO enhances the absorption of other substances through the skin. Therefore, avoid applying DMSO near or with other topical medications, chemicals, or personal care products, as it could increase their systemic absorption and lead to unexpected effects.
Wearing protective gloves, such as nitrile gloves, during handling and application is advisable. This protects hands from direct exposure and prevents inadvertent transfer of other substances. Individuals who are pregnant or nursing, or those with pre-existing medical conditions, should consult a healthcare professional before using DMSO.
Proper Storage and Handling
Correct storage of DMSO is important to maintain stability and prevent contamination. Store DMSO in appropriate containers, ideally glass or high-density polyethylene (HDPE) plastics, as it can react with other plastic types. Keep it in a cool, dark place, away from direct sunlight and extreme temperatures.
DMSO has a relatively high freezing point of approximately 18.5°C (65.3°F) and may solidify at room temperature. If it freezes, gently warm the container, such as by placing it in warm water, to return it to liquid form. Avoid heating directly or rapidly. Always keep DMSO out of reach of children and pets to prevent accidental ingestion or exposure.