Deglycyrrhizinated Licorice (DGL) is a specialized extract of the licorice plant, Glycyrrhiza glabra. This supplement is created by removing the compound glycyrrhizin, which is responsible for the traditional licorice root’s potential side effects, such as elevated blood pressure and fluid retention. The processing ensures that DGL retains the beneficial components for digestive support without those specific cardiovascular risks. DGL has become a popular natural intervention focused on maintaining the health of the gastrointestinal tract.
Understanding DGL’s Primary Use
The main therapeutic application of DGL is its ability to support the body’s natural mechanisms for protecting the digestive tract lining. DGL does not function as a direct antacid, but rather helps reinforce the mucosal barrier. It is thought to stimulate the production and secretion of mucin, a protective substance that coats the esophagus, stomach, and intestines. This enhanced mucus layer provides a physical shield against the erosive effects of stomach acid and other irritants.
DGL’s mechanism of action is cytoprotective, meaning it helps protect cells from damage. It promotes the growth and regeneration of mucosal cells, which is why it has been studied for conditions involving damage to the lining, such as peptic ulcers. The active components, which include flavonoids, also possess anti-inflammatory properties that help soothe irritated tissue. This local protective effect makes DGL a preferred option for people seeking relief from mild heartburn or general gastric discomfort.
Standard Daily Dosage Recommendations
For adults, the generally recommended daily intake of DGL is divided into multiple doses throughout the day, often taken before meals. A typical single dose ranges from 380 milligrams (mg) to 760 mg of the deglycyrrhizinated extract. This dose is repeated two to three times daily, leading to a total daily intake that can range from approximately 760 mg up to 2280 mg for acute support.
The form of DGL is significant, especially for addressing issues in the upper digestive tract. Chewable tablets are widely recommended over capsules or powders because the act of chewing mixes the DGL with saliva. This mixing is considered necessary to activate the compounds that stimulate local mucosal defense before they are swallowed. Taking DGL about 20 minutes before a meal is advised because this timing allows the protective barrier to form before the digestive process begins.
Users typically continue with the full daily dosage for a period of 8 to 16 weeks to support complete healing of the mucosal lining. Once the desired effect is achieved, the dose may be reduced to a lower maintenance level or discontinued entirely, depending on individual needs. Consistency in taking DGL at the recommended timing before meals is often linked to better results.
Factors Influencing Individual Intake
The standard dosage provides a starting point, but individual needs often require adjustment based on several factors, including the specific condition being addressed. A person using DGL for short-term, acute relief of mild irritation might find a lower dose sufficient. Conversely, someone using DGL to support the healing of a more established issue, such as a gastric ulcer, may require a higher dose within the recommended maximum range.
Body weight and size can also influence how a person responds to a standard dose. While DGL is generally well-tolerated, it is advisable to begin with the lowest effective dosage and gradually increase it only if symptoms persist. This titration helps the user find the optimal intake level that provides relief without unnecessary excess.
The choice of product form is another factor; chewable tablets are prioritized for upper GI complaints, while capsules might be considered for lower intestinal support. Concurrent use with other medications or supplements should also be discussed with a healthcare professional, as DGL can potentially interact with certain drugs. Seeking personalized guidance ensures the dosage is appropriate for the individual’s overall health profile.
Safety Considerations and Maximum Limits
The deliberate removal of glycyrrhizin from DGL makes it a safer alternative to whole licorice root for long-term or high-dose use. Because the compound linked to mineralocorticoid effects—sodium retention and potassium loss—is absent, the risk of developing elevated blood pressure is negligible at typical dosages. This safety profile is a primary reason DGL is recommended over traditional licorice preparations for digestive health.
While DGL is generally safe, it is important to respect the established maximum intake levels. In adults, the maximum single dose for DGL extract is typically 1520 mg, taken up to three times daily, totaling 4560 mg per day. Exceeding this amount is not recommended and does not necessarily increase efficacy. Users should discontinue DGL and consult a professional if their digestive symptoms worsen, persist beyond a few weeks of use, or if they experience any unexpected adverse effects.