Tusi (also called pink cocaine or tuci) doesn’t have a single detection window because it isn’t a single drug. Every batch contains a different mix of substances, and each one clears your body on its own timeline. The most common ingredients are ketamine and MDMA, which can show up on a urine test for anywhere from 1 to 14 days depending on the substance and type of test. But some batches contain cocaine, methamphetamine, or fentanyl, each with its own detection window, and you won’t know what’s in a given sample without lab testing.
Why There’s No Single Answer
Tusi started as a slang term for 2C-B, a synthetic hallucinogen. Today, according to the DEA, pink cocaine rarely contains 2C-B at all. Instead, it’s a branded cocktail that varies wildly from batch to batch. DEA laboratory testing has identified pink powders containing combinations like ketamine and MDMA, methamphetamine with ketamine and MDMA, cocaine and fentanyl, and fentanyl with xylazine. The Sinaloa Cartel has exploited the “tusi” branding to sell whatever combination is cheapest to produce at a given time.
This means two people taking what looks like the same pink powder could have completely different substances in their bodies. The only reliable way to estimate how long tusi will stay in your system is to consider the detection windows for each ingredient that commonly appears in it.
Detection Windows by Ingredient
Ketamine
Ketamine is the most frequently identified ingredient in tusi. The drug itself has a very short half-life and clears from the bloodstream quickly. In urine, ketamine is typically detectable for 1 to 3 days after use. However, the body breaks ketamine down into a metabolite called norketamine, which lingers much longer. Research shows norketamine can be detected in urine for up to 14 days after a single dose. Whether a drug test picks up norketamine depends on the type of panel used, since standard workplace screens don’t always test for ketamine.
MDMA
MDMA (ecstasy or molly) is the second most common tusi ingredient. It shows up in urine for roughly 1 to 3 days after use. Blood and saliva tests have shorter windows, generally around 1 to 2 days. MDMA is typically screened under the amphetamines category on standard drug panels, so it’s more likely to be flagged than ketamine on a routine test.
Methamphetamine
Some tusi batches contain methamphetamine, which has a longer detection window than MDMA. Meth is generally detectable in urine for 3 to 5 days, though heavy or repeated use can extend that. It will show up on any standard drug test that screens for amphetamines.
Cocaine
When cocaine is present in tusi, it’s detectable in blood and saliva for up to 2 days. Urine tests pick up cocaine’s primary metabolite for 2 to 4 days after occasional use, but that window stretches to roughly 2 weeks with heavy or binge use.
Fentanyl
Fentanyl is the most dangerous possible ingredient in tusi, and the DEA has confirmed its presence in some samples. Fentanyl typically appears in urine for 1 to 3 days, though this varies with the amount consumed. Standard workplace drug panels don’t always screen for fentanyl. It requires a specific test.
Detection by Test Type
The type of test matters as much as the substance itself. Here’s how the common testing methods compare for the ingredients most often found in tusi:
- Urine: The most common test. Depending on which substances are in the batch, detection ranges from 1 to 3 days for the parent drugs and up to 14 days for certain metabolites like norketamine.
- Blood: Shorter detection windows, generally up to 2 days for most tusi components. Blood tests are less common outside of emergency or legal settings.
- Saliva: Similar to blood, with a window of roughly 1 to 2 days for most substances.
- Hair: Hair testing provides a long-term record of drug use. It takes about 14 days for drugs to appear in the hair shaft after use, and every centimeter of hair growth represents approximately one month of history. A standard hair test covering 1.5 inches of growth can detect use going back roughly 90 days.
Factors That Affect Clearance Time
The timelines above are averages. Your actual clearance time depends on several biological variables. Liver function plays the biggest role, since the liver metabolizes most of these substances. Kidney function matters too, as the kidneys filter metabolites out through urine. People with liver or kidney disease will clear drugs more slowly.
Hydration levels affect the volume of distribution in your body, which can influence how quickly metabolites concentrate in urine. Body composition plays a role as well: some substances and their byproducts are stored in fat tissue, so people with higher body fat percentages may retain certain drugs longer. Age, overall metabolism, and whether you’re taking other medications that compete for the same liver enzymes can also shift the timeline in either direction.
Frequency of use is one of the strongest predictors. A single exposure clears faster than repeated dosing over days or weeks, which allows metabolites to accumulate in tissues and extends the detection window significantly.
Why Tusi Carries Extra Risk for Testing
The unpredictable composition of tusi creates a unique problem for anyone concerned about drug testing. You could test positive for substances you didn’t knowingly take. Someone who believes they used “just ketamine” might test positive for methamphetamine or fentanyl. A standard 5-panel workplace test screens for amphetamines, cocaine, and opioids, all of which have been documented in tusi samples. Even if ketamine wouldn’t normally trigger a standard panel, the other ingredients in the same powder might.
The worst-case scenario involves fentanyl contamination. Fentanyl is active at microgram doses, meaning even a small amount in a tusi batch can produce dangerous effects and leave a detectable trace. The 2025 DEA National Drug Threat Assessment confirms that fentanyl continues to appear in tusi mixtures produced by major trafficking organizations.
Because no two batches are identical, the honest answer to “how long does tusi stay in your system” is that it depends entirely on what was actually in the powder you took. The safest assumption is that some component could be detectable in urine for up to 14 days, and in hair for up to 90 days.