How Long Can a Mycoplasma Infection Last?

Mycoplasma are small bacteria lacking a rigid cell wall, which makes them resistant to many common antibiotics. They can cause various infections in humans. This article discusses how long Mycoplasma infections typically last and the factors influencing their duration.

Understanding Mycoplasma Infections

Mycoplasma are microscopic, self-replicating bacteria without the protective cell wall found in most other bacteria. This structural difference affects how they interact with the body and which antibiotics are effective. Mycoplasma species are often found on human mucous membranes, affecting respiratory, urinary, and genital tracts. Infections spread differently depending on the species. For example, Mycoplasma pneumoniae, a common cause of respiratory infections, spreads through airborne droplets. Mycoplasma genitalium is primarily transmitted sexually and infects reproductive organs.

Factors Influencing Infection Duration

The duration of a Mycoplasma infection varies significantly based on several factors. The specific type of Mycoplasma plays a role. Mycoplasma pneumoniae infections, known as “walking pneumonia,” typically show symptoms one to four weeks after exposure, lasting several weeks. A cough may persist for months. In contrast, Mycoplasma genitalium infections can remain asymptomatic for months to years if untreated.

An individual’s immune system impacts how quickly the body clears the infection. A healthy immune response limits duration, while a weakened immune system (due to age, health conditions, or medications) can lead to prolonged or severe infections.

Timely and appropriate treatment is an important factor. Since Mycoplasma lack cell walls, antibiotics like penicillin are ineffective. Specific classes of antibiotics, such as macrolides or tetracyclines, are needed. Starting the correct antibiotic early can shorten the symptomatic period and hasten recovery.

Adherence to the prescribed treatment regimen is also important. Completing the full course of medication, even if symptoms improve, ensures bacterial eradication and prevents recurrence or antibiotic resistance. The presence of other concurrent infections can complicate the clinical picture and extend a Mycoplasma infection’s duration.

Addressing Persistent Infections

A Mycoplasma infection is persistent when symptoms do not resolve after typical treatment or recur. Factors contributing to persistence include incomplete or incorrect treatment, allowing bacteria to survive.

Antibiotic resistance is a growing concern, especially with Mycoplasma genitalium, which shows increasing resistance to standard treatments. This resistance means the chosen antibiotic may not clear the infection. Misdiagnosis or unidentified co-infections can also lead to treatment failures and prolonged illness. Re-exposure or reinfection, particularly with sexually transmitted Mycoplasma, can also cause new symptoms.

Managing persistent Mycoplasma infections involves re-evaluation by a healthcare professional. This may include further testing to confirm diagnosis, identify the specific strain, and assess for antibiotic resistance. Based on findings, a different or longer antibiotic course may be prescribed. Symptom management alleviates discomfort. Follow-up testing is often recommended to confirm eradication, especially for Mycoplasma genitalium, where a test of cure is advised four weeks after treatment. If left unaddressed, persistent infections can lead to chronic symptoms and serious health issues, such as chronic cough or, for Mycoplasma genitalium, pelvic inflammatory disease and potential infertility.

When to Seek Professional Help

Consult a healthcare professional if new or worsening symptoms suggestive of a Mycoplasma infection develop. Early diagnosis leads to more effective and timely treatment, potentially shortening illness duration.

Seek medical attention if symptoms do not improve or worsen despite initial treatment. This could indicate an ineffective antibiotic, antibiotic resistance, or another underlying issue. Severe symptoms, such as difficulty breathing or a high fever, warrant immediate medical attention. Individuals concerned about potential exposure to Mycoplasma, especially sexually transmitted types, should seek testing and guidance from a healthcare provider.