How a Nuclear Stress Test Is Done and What to Expect

A nuclear stress test is an imaging procedure that provides a detailed view of blood flow to the heart muscle, both at rest and during periods of increased demand, or “stress.” It uses a small amount of radioactive material, called a radiotracer, to identify areas where blood flow might be reduced or where heart tissue may have been affected. This test is a common method for assessing heart health, diagnosing conditions such as coronary artery disease, and evaluating the effectiveness of existing treatments.

Getting Ready for Your Test

Preparing for a nuclear stress test involves several steps to ensure accurate results. Patients are typically advised to avoid eating or drinking anything for a few hours before the appointment. Water or other clear, non-caffeinated liquids may be permitted during this fasting period.

A crucial preparation involves abstaining from caffeine for 12 to 24 hours prior to the test. This includes coffee, tea, sodas (even those labeled decaffeinated), chocolate, and certain over-the-counter pain medications that contain caffeine. Patients should also discuss all current medications with their healthcare provider, as some, such as beta-blockers, calcium channel blockers, or certain diabetes drugs, may need to be temporarily stopped. Do not discontinue any prescribed medication without first consulting a doctor.

For the test day, wearing comfortable, loose-fitting clothing and walking shoes is recommended. Patients should also avoid applying lotions or creams to their chest area. The entire appointment can last between three to four hours, and sometimes longer, so planning for this duration is advisable.

Undergoing the Stress Portion

During the nuclear stress test, medical staff monitor heart activity. Electrodes are placed on the chest to track the heart’s electrical signals via an electrocardiogram (EKG), and a blood pressure cuff is used to measure blood pressure throughout the procedure. An intravenous (IV) line is also inserted for medication and radiotracer administration.

The “stress” on the heart can be induced through exercise or with specific medications. If exercise is feasible, patients will walk on a treadmill or ride a stationary bike. Exercise continues until the heart rate reaches a predetermined target or if symptoms develop.

For individuals unable to exercise, a pharmacological stress agent is administered intravenously. Common medications include adenosine, dobutamine, dipyridamole, or regadenoson. Adenosine, dipyridamole, and regadenoson work by dilating the coronary blood vessels, thereby increasing blood flow to the heart. Dobutamine, conversely, increases the heart’s rate and pumping force, mimicking the effects of physical exertion. Patients might experience temporary sensations like flushing, a mild headache, shortness of breath, or slight chest pressure.

At the peak of stress, or after initial rest images are captured, a small amount of radioactive tracer, such as Technetium-99m or Thallium-201, is injected through the IV line. This radiotracer travels through the bloodstream and is absorbed by the heart muscle cells.

Capturing the Images

Following the stress portion and radiotracer injection, specialized imaging equipment is used to capture pictures of the heart. A gamma camera, or a SPECT/PET scanner, detects the radiation emitted by the radiotracer within the heart.

Images are acquired at two distinct times to provide a comprehensive assessment. The first set of images, known as “rest images,” is taken after an initial radiotracer injection while the patient is calm and relaxed. This usually occurs a few minutes after the injection. The second set, called “stress images,” is captured after the heart has been stressed by exercise or medication and a second dose of the radiotracer has been administered. There is typically a waiting period of 15 to 45 minutes after the stress injection before these images are taken, allowing the tracer to circulate effectively.

During the imaging process, the patient lies still on a table, often with their arms positioned above their head. The camera rotates around the chest to capture detailed views of the heart from multiple angles. Maintaining stillness is important for obtaining clear and precise images.

The images reveal how blood flows through different sections of the heart muscle during both resting and stressed conditions. Areas with normal blood flow show an even distribution of the radiotracer. Conversely, areas with reduced blood flow, due to blockages or damaged tissue, appear as “cold spots” or regions with lower tracer uptake. By comparing the rest and stress images, medical professionals can determine if any reduced blood flow is temporary, occurring only during stress, or if it indicates permanent damage from a prior heart event.

What Happens After the Procedure

Once the nuclear stress test is complete, patients can generally return to their usual daily routines unless otherwise instructed by their healthcare provider. It is often recommended to increase fluid intake, such as drinking plenty of water, to help the body naturally eliminate the radiotracer.

The small amount of radioactive material used in the test leaves the body over time, primarily through urine and stool. The rate at which the tracer clears depends on the specific type used, but it typically ranges from a few hours to a few days. For instance, Technetium-99m, a commonly used tracer, has a half-life of approximately six hours.

The images captured during the test are sent to a specialist, such as a cardiologist or radiologist, for thorough analysis. Patients can typically expect their results to be sent to their referring doctor within a few days. The referring doctor will then discuss the findings with the patient and outline any necessary follow-up steps, which may include adjustments to treatment plans or recommendations for further diagnostic evaluations.