Does Valacyclovir Make You Sleepy? What to Know

Valacyclovir is an antiviral medication prescribed to manage infections caused by herpes viruses, including genital herpes, cold sores (herpes labialis), and shingles (herpes zoster). This medication works by slowing the growth and spread of the virus, helping the body to fight the infection and promote healing of sores. While valacyclovir does not cure these viral infections, it can lessen the symptoms and help them heal faster.

Valacyclovir and Drowsiness

Drowsiness is not typically listed as a common side effect of valacyclovir. However, some individuals may experience dizziness, which can sometimes be perceived as a form of lightheadedness or contribute to a feeling of being unwell, potentially leading to a sense of drowsiness. Clinical trials have indicated that dizziness, when it occurs, is generally rare and mild.

While direct drowsiness is uncommon, valacyclovir can, in rare instances, affect the central nervous system (CNS), leading to neuropsychiatric symptoms. These effects are more likely to occur at higher doses or in individuals with pre-existing kidney problems, as the kidneys are responsible for clearing the drug from the body. Such CNS effects can include confusion, agitation, or hallucinations, which could indirectly impact one’s alertness.

The active compound, acyclovir, can accumulate if kidney function is impaired, leading to higher concentrations that may contribute to these neurological effects. This highlights the importance of proper dosing, especially for those with kidney disease. If CNS symptoms like unusual confusion or disorientation develop, it is important to seek medical attention.

Other Potential Side Effects

Beyond the potential for dizziness or rare central nervous system effects, valacyclovir can cause other side effects. Common ones include headache, nausea, and stomach pain. Some individuals may also experience vomiting or diarrhea. These common side effects are typically mild and often resolve on their own as the body adjusts to the medication.

Less common but more serious side effects can also occur, which warrant immediate medical attention. These include signs of an allergic reaction such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. Valacyclovir can also, in rare cases, lead to kidney problems, sometimes indicated by little or no urination, swelling in the feet or ankles, or feeling tired.

Managing Drowsiness and When to Seek Medical Advice

If you experience drowsiness or dizziness while taking valacyclovir, it is advisable to avoid activities that require complete alertness, such as driving or operating heavy machinery. Staying well-hydrated by drinking plenty of fluids is also recommended, as it supports kidney function and can help prevent the accumulation of the drug, which might contribute to some side effects. Do not make any changes to your prescribed dosage without first consulting your healthcare provider.

It is important to contact your doctor if drowsiness becomes severe, persistent, or is accompanied by other concerning symptoms. These might include significant confusion, aggression, hallucinations, problems with speech, or seizures. Additionally, any signs of kidney issues, such as decreased urine output or swelling, or symptoms of a serious allergic reaction, require immediate medical evaluation. Your healthcare provider can assess whether your symptoms are related to the medication and determine the best course of action.