Methylsulfonylmethane (MSM) is a common dietary supplement and an organic sulfur-containing compound found naturally in plants, animals, and the human body. As a supplement, MSM delivers sulfur, a mineral needed for numerous bodily processes, including the formation of connective tissue. Many people wonder whether taking MSM can lead to weight gain. This article examines the current scientific evidence regarding MSM consumption and changes in body weight.
Answering the Weight Gain Concern
Clinical research does not support the claim that supplementing with MSM directly causes an increase in body weight or fat mass. MSM is not a calorie-dense macronutrient and does not significantly alter the metabolic pathways responsible for fat storage. Human trials involving overweight and obese adults have shown no adverse changes in body mass index (BMI) or fat mass when participants take standard doses.
The compound is considered metabolically neutral, meaning it does not stimulate the production or storage of fat tissue. Some animal studies suggest MSM may possess anti-obesity activity by improving insulin sensitivity and suppressing metabolic disorders. These findings indicate the compound is more likely to have a neutral or potentially beneficial effect on metabolic health.
Anecdotal reports of minor, temporary weight fluctuations are likely linked to mild side effects such as bloating or water retention, which are not true gains in body fat. By reducing pain and inflammation, MSM can indirectly support healthy weight management. Reduced joint discomfort allows individuals to maintain or increase their exercise levels, naturally supporting a healthy weight.
Primary Therapeutic Applications of MSM
The main reason people take MSM supplements is for its anti-inflammatory and antioxidant properties, linked to its ability to donate sulfur. Sulfur is an important component of collagen and keratin, the structural proteins that form cartilage, skin, hair, and nails. This capacity helps the body maintain and repair connective tissues.
Joint Health and Osteoarthritis
MSM is widely used to help manage symptoms associated with joint degeneration, such as osteoarthritis. Multiple studies have demonstrated that regular supplementation can significantly decrease joint pain, stiffness, and swelling in affected areas like the knees and hips. This benefit is attributed to the compound’s ability to reduce the expression of inflammatory molecules.
Muscle Recovery
The supplement is also popular among physically active individuals for its role in supporting muscle recovery after strenuous exercise. By mitigating exercise-induced inflammation and oxidative stress, MSM can help reduce muscle soreness and damage. Daily intake helps tissues recover faster, allowing for a quicker return to training.
Other Potential Side Effects and Safety Profile
MSM is well-tolerated by most people when taken at recommended dosages, typically up to four grams daily. When side effects occur, they are usually mild and primarily involve the digestive system. Common complaints include mild gastrointestinal upset, such as nausea, diarrhea, or bloating, especially when starting the supplement or taking higher doses.
Some individuals may also experience minor issues like headaches, fatigue, or difficulty concentrating. These effects are often transient and tend to resolve as the body adjusts to the supplementation. To minimize the risk of digestive issues, it is recommended to take MSM with food and begin with a lower daily dose, gradually increasing it.
While rare, certain safety precautions should be noted. Women who are pregnant or breastfeeding should exercise caution and consult with a healthcare provider due to insufficient research. Additionally, individuals taking blood-thinning medications should seek medical advice, as MSM may possess mild anticoagulant properties that could increase the risk of bleeding.