Hexahydrocannabinol (HHC) is a semi-synthetic cannabinoid, typically produced by hydrogenating THC or converting hemp-derived Cannabidiol (CBD). HHC’s molecular structure is very similar to Delta-9 Tetrahydrocannabinol (THC), resulting in comparable psychoactive effects and side effects. This article examines whether HHC shares the common visible side effect of traditional cannabis use.
Does HHC Affect Eye Appearance?
The direct answer is that HHC can indeed cause eye redness, similar to the effect seen with Delta-9 THC consumption. HHC interacts with the body’s endocannabinoid system, which is the same pathway responsible for the ocular effects of other cannabinoids. The severity of this redness often depends on the dosage consumed and the individual’s unique biological sensitivity to the compound.
This visible change in eye appearance is not universal. Higher doses are more likely to result in a noticeable reddening of the eyes. This side effect is a direct result of HHC interacting with cannabinoid receptors that regulate several physiological processes, including blood flow.
The Physiological Reason for Redness
The physical change that makes the eyes appear red is systemic vasodilation, the widening of blood vessels throughout the body. When HHC enters the bloodstream, it interacts with cannabinoid receptors, specifically the CB1 receptors found in the body’s endocannabinoid system. This interaction causes a decrease in overall blood pressure.
As the blood pressure drops, the tiny blood vessels and capillaries in the conjunctiva, the clear membrane covering the white of the eye, expand to accommodate the increased blood flow. This expansion makes them much more prominent and visible against the white background of the sclera, creating the characteristic bloodshot look.
This process of vasodilation is also responsible for an associated effect: a temporary lowering of intraocular pressure (IOP). The temporary pressure drop and the eye redness are two manifestations of the same underlying physiological response to the cannabinoid.
HHC vs. THC: Differences in Ocular Effects
HHC and Delta-9 THC both produce their effects by binding to the CB1 receptors, but they differ in their molecular structure and receptor affinity. HHC is created by adding hydrogen atoms to the THC molecule, which slightly alters its shape and stability. This structural difference means HHC has a lower binding affinity for the CB1 receptor than Delta-9 THC, leading to lower overall potency.
Because HHC is often less potent than Delta-9 THC, the resulting physiological effects, including the drop in blood pressure and subsequent vasodilation, may be less intense. The eye redness associated with HHC may be milder compared to the effects experienced after consuming Delta-9 THC. The intensity of the redness is directly linked to the degree of systemic vasodilation, which is proportional to the cannabinoid’s potency and the dosage consumed.
While the mechanism for eye redness is identical to that of traditional cannabis, the severity of the visible effect can be diminished. However, the purity and concentration of commercially available HHC products can vary widely. Products with a higher concentration of the active HHC isomer may produce ocular effects closer in intensity to those of Delta-9 THC.
Strategies for Reducing Eye Redness
Since the redness is caused by vasodilation, the most effective way to counteract the effect is to use products that cause vasoconstriction, or the narrowing of blood vessels. Strategies for reducing eye redness include:
- Using over-the-counter eye drops formulated with vasoconstrictors like naphazoline or tetrahydrozoline. These active ingredients shrink the dilated capillaries, quickly reducing the visible bloodshot appearance.
- Applying a cool compress or a washcloth soaked in cold water gently over the closed eyes. The cold temperature naturally helps constrict the blood vessels.
- Staying properly hydrated by drinking water, as dehydration can exacerbate eye dryness and irritation.
- Using simple lubricating eye drops, sometimes called artificial tears, to soothe the eyes and restore moisture if irritation and dryness occur.