Gonadorelin is a synthetic hormone chemically identical to the naturally occurring Gonadotropin-releasing Hormone (GnRH). As a delicate peptide medication, its effectiveness and safety depend highly on correct handling and storage conditions. Understanding the difference in storage requirements between the unmixed powder form and the liquid solution form is important. The drug’s stability changes dramatically once it is mixed, which directly influences whether refrigeration is required.
What is Gonadorelin and How it Functions
Gonadorelin is a medication that mimics the structure of the body’s natural Gonadotropin-releasing Hormone (GnRH), a decapeptide produced in the hypothalamus. Its primary function is to stimulate the pituitary gland to release Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). This action regulates the function of the gonads.
The drug is used clinically as a diagnostic agent to evaluate pituitary function. It is also employed in fertility treatments for conditions like hypothalamic amenorrhea, where the body lacks sufficient GnRH. By mimicking the natural pulsatile release of GnRH, Gonadorelin helps restore hormonal signaling necessary for ovulation and sperm production.
Storage Instructions for Unmixed Powder
Gonadorelin is typically supplied as a lyophilized (freeze-dried) powder in a sealed glass vial. Before any liquid diluent is added, the drug is significantly more stable than the liquid solution. The unmixed powder generally does not require refrigeration for short-term storage, often being stable when stored below 25°C (77°F) or at controlled room temperature.
The powder must be kept in its original packaging and protected from excessive light and moisture. Extreme heat must be avoided, as high temperatures can degrade the peptide structure over time. Similarly, the powder should not be subjected to freezing. Always check the expiration date on the original carton, as the powder can remain potent for years when stored correctly.
Handling and Shelf Life After Reconstitution
The storage requirements for Gonadorelin change substantially once the powder is mixed, or “reconstituted,” with the provided diluent. After mixing, the medication becomes far less stable, making refrigeration a requirement for maintaining its potency. The liquid solution must be stored in a refrigerator at a temperature range of 2°C to 8°C (36°F to 46°F).
Shelf Life Limitations
The shelf life of the liquid solution is significantly limited, often lasting only 24 hours to a few days, depending on the specific brand and concentration. Some preparations may retain stability for a longer period, sometimes up to 30 days when refrigerated. Individual product instructions must be followed exactly.
Any unused portion of the liquid medication must be discarded after the specified shelf life has passed, even if it has been continuously refrigerated.
Handling and Integrity
Proper handling during mixing is important to preserve the drug’s integrity. The lyophilized powder should be gently dissolved by swirling or rolling the vial, never by shaking it vigorously, which can cause denaturation of the peptide.
The reconstituted solution should never be frozen, as the formation of ice crystals can physically damage the delicate protein structure, rendering the medication ineffective. If the solution appears discolored or contains any visible particles after reconstitution, it must be discarded and not administered.