Does Gluten Cause Acid Reflux? The Scientific Connection

Acid reflux occurs when stomach contents, including acid, flow backward into the esophagus, causing heartburn. While many factors contribute, gluten can trigger symptoms in specific individuals with certain underlying conditions.

Conditions Linking Gluten and Acid Reflux

For some, gluten consumption contributes to acid reflux due to specific medical conditions. Celiac disease is an autoimmune disorder where ingesting gluten (a protein in wheat, barley, and rye) damages the small intestine, impairing nutrient absorption and leading to digestive issues like acid reflux. This damage can affect digestive tract motility and the lower esophageal sphincter, which normally prevents stomach acid from flowing back up. Acid reflux symptoms are common in people with untreated celiac disease.

Non-celiac gluten sensitivity (NCGS) describes a condition where individuals experience gastrointestinal symptoms, including acid reflux, after consuming gluten, without the autoimmune response or intestinal damage of celiac disease. While the exact mechanisms are not fully understood, symptoms are real. Systemic inflammation or altered immune responses in the gut may influence digestive functions and contribute to reflux in NCGS.

Other Common Causes of Acid Reflux

Acid reflux often stems from various factors beyond gluten. Dietary choices frequently influence reflux symptoms. Consuming large or fatty meals, spicy foods, caffeine, alcohol, chocolate, or peppermint can relax the lower esophageal sphincter, allowing stomach acid to escape into the esophagus. Citrus fruits and tomatoes are also common dietary triggers.

Lifestyle habits also play a significant role. Eating too close to bedtime, being overweight or obese, and smoking can increase the likelihood of acid reflux. Stress can also contribute. Physiological factors like a hiatal hernia (where part of the stomach pushes through the diaphragm) or a weakened lower esophageal sphincter can lead to chronic acid reflux. Certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or specific blood pressure medications, can also induce or worsen symptoms.

Determining if Gluten is a Factor

If acid reflux symptoms are persistent, consult a healthcare provider to identify the underlying cause and determine if gluten is a factor. For suspected celiac disease, diagnostic tests include blood tests for specific antibodies (e.g., tissue transglutaminase IgA). If blood tests suggest celiac disease, an endoscopy with a small intestine biopsy is often performed to look for intestinal lining damage. Continue consuming gluten before these tests, as removing it prematurely can lead to inaccurate results.

For non-celiac gluten sensitivity, there is no specific diagnostic test. Diagnosis involves exclusion, ruling out celiac disease and wheat allergy first. If symptoms persist, a healthcare provider might recommend a supervised gluten elimination diet. This involves removing gluten for two to six weeks, monitoring symptoms, then reintroducing it to see if symptoms, including acid reflux, return or worsen, confirming if gluten is a trigger.

Strategies for Managing Gluten-Related Reflux

For individuals whose acid reflux is linked to gluten, managing dietary intake is important. If diagnosed with celiac disease, a strict, lifelong gluten-free diet is necessary to allow the small intestine to heal and alleviate symptoms, including reflux. Consistent adherence helps prevent further intestinal damage and improves acid reflux.

For non-celiac gluten sensitivity, a reduced or modified gluten intake may suffice, depending on individual tolerance. This might involve avoiding major gluten sources while allowing small amounts that do not trigger symptoms. Alongside dietary adjustments, general lifestyle modifications can help manage reflux. These include eating smaller, more frequent meals, avoiding personal trigger foods, elevating the head of the bed during sleep, and maintaining a healthy weight. Medical follow-up and guidance from a registered dietitian specializing in gluten-free diets can provide valuable support.