Deglycyrrhizinated Licorice (DGL) is a popular herbal supplement often sought for its digestive support properties. Individuals commonly use it to alleviate symptoms such as stomach discomfort or heartburn. However, a frequent question arises regarding its potential impact on blood pressure, especially given that traditional licorice can affect it.
What is DGL?
DGL, short for deglycyrrhizinated licorice, is a modified form derived from the licorice plant, Glycyrrhiza glabra. The key characteristic of DGL is the removal of glycyrrhizin, a compound naturally present in whole licorice. As a supplement, DGL is primarily utilized for its soothing effects on the gastrointestinal tract, supporting issues like stomach irritation and duodenal ulcers.
DGL Versus Whole Licorice: The Key Difference
The crucial distinction between DGL and whole licorice lies in the presence of glycyrrhizin. This compound inhibits an enzyme called 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which is responsible for inactivating cortisol in the kidneys. When 11β-HSD2 is inhibited, active cortisol levels increase, leading to heightened activation of mineralocorticoid receptors.
This heightened activity mimics the effects of excess aldosterone, a hormone that regulates sodium and potassium balance. Consequently, the body retains more sodium and water while losing potassium, which can result in elevated blood pressure. Even relatively small daily amounts of glycyrrhizin, such as 100 mg, have been shown to increase blood pressure in healthy individuals. DGL, by having glycyrrhizin removed, avoids this mechanism, thus eliminating the typical blood pressure-raising effects associated with traditional licorice.
DGL and Blood Pressure: The Current Understanding
Because the compound glycyrrhizin is removed during its processing, DGL is not typically associated with the blood pressure-elevating effects seen with whole licorice. Scientific consensus generally indicates that DGL is safe for most individuals regarding blood pressure when used appropriately. Unlike regular licorice root, DGL does not generally cause electrolyte imbalances, so sodium and potassium levels tend to remain normal. Studies generally show DGL to be safe for those with or without high blood pressure.
Important Considerations for Use
Individuals considering DGL should adhere to recommended dosages provided by the manufacturer. Consulting a healthcare professional before starting any new supplement, including DGL, is advisable. This is particularly important for those with pre-existing health conditions, such as high blood pressure, heart disease, or kidney issues.
DGL may interact with certain medications, including diuretics, corticosteroids, blood pressure drugs, and blood thinners like warfarin. Pregnant or breastfeeding individuals should also seek medical advice before using DGL. Ensuring the purchase of DGL from reputable sources helps guarantee product quality and that the glycyrrhizin content is indeed minimal.