Compounded semaglutide is a medication prepared by a specialized pharmacy to meet individual patient needs. This customization can involve adjusting dosage or altering formulation, especially when standard, commercially available options are not suitable. While it contains the same active ingredient as its brand-name counterparts, its preparation process means specific handling instructions are important for maintaining quality and ensuring effectiveness.
Refrigeration Guidelines
Compounded semaglutide generally requires refrigeration to maintain its stability and potency. The recommended temperature range for storage is typically between 36°F and 46°F (2°C and 8°C). This range helps preserve the medication’s chemical integrity before first use. Unopened vials should remain refrigerated until their Beyond-Use Date (BUD), a specific date assigned by the compounding pharmacy.
Once a vial is opened, storage guidelines may shift, though refrigeration often remains important. Many compounded formulations are stable in the refrigerator for 28 to 60 days after the first use. Some specific formulations might allow for limited storage at room temperature, generally not exceeding 77°F (25°C), for up to 60 days. It is important to always follow the precise storage instructions and Beyond-Use Date provided by the compounding pharmacist, as these can vary based on the specific formulation and preservatives used.
Why Proper Storage Matters
Precise storage conditions for compounded semaglutide are important due to its sensitive molecular structure. As a peptide-based medication, its active ingredients are susceptible to degradation when exposed to inappropriate temperatures. Higher temperatures can cause peptide molecules to break down, reducing the medication’s potency. This degradation means the medication may become less effective at regulating blood sugar levels or aiding in weight management.
Improper storage can also lead to bacterial or fungal growth if not kept within recommended conditions. Freezing semaglutide causes irreversible damage to its molecular structure, rendering it ineffective. If accidentally frozen, it should not be used, as its therapeutic benefits may be lost. Maintaining the correct temperature ensures the medication remains safe and delivers its intended therapeutic effects.
Beyond Refrigeration: Additional Storage Tips
Beyond temperature control, several other factors influence the stability and safety of compounded semaglutide. Protecting the medication from light exposure is important, as direct sunlight can degrade the active ingredients. Keeping the medication in its original packaging helps shield it from light and maintain its quality. Also, keep compounded semaglutide away from extreme heat sources and damp areas.
Always visually inspect the medication before use for any changes in color, clarity, or the presence of particles, which could indicate degradation or contamination. Compounded medications are assigned a Beyond-Use Date (BUD) rather than an expiration date; it is important to discard any medication past this date. Finally, always store compounded semaglutide out of the reach of children and pets to prevent accidental ingestion or misuse.