Cannabigerol (CBG) is one of the many naturally occurring compounds found in the Cannabis sativa plant. This article explores the science behind this cannabinoid to answer the common question about its psychoactive potential. The following sections detail why CBG does not produce intoxication and what physical sensations users can expect instead.
CBG: The Absence of Intoxication
The definitive answer to whether CBG gets a person “stoned” is no, as it is classified as a non-intoxicating cannabinoid. The feeling of being “stoned” or “high” is a psychoactive effect characterized by altered perception, euphoria, and impairment. This state is primarily associated with high levels of Delta-9-tetrahydrocannabinol (THC). CBG does not induce this effect, meaning it will not cause the heavy, disorienting, or “couch-lock” sensation linked to strong THC use.
The lack of intoxication makes CBG a suitable option for individuals seeking cannabinoid effects without compromising mental clarity or daily function. CBG is sometimes used alongside THC because it may help temper or reduce unwanted side effects, such as anxiety or paranoia. Products containing only CBG will not deliver the euphoric or sedating effects that define a cannabis high.
How CBG Interacts with Receptors
CBG’s lack of psychoactivity stems from its mechanism of action within the body’s endocannabinoid system (ECS). Intoxication is caused by the strong binding of THC to the Cannabinoid 1 (CB1) receptor, which is densely located in the brain and central nervous system. CBG interacts with the CB1 receptor much more weakly than THC.
CBG is not a potent activator of the CB1 receptor, meaning it does not stimulate the receptor strongly enough to trigger the psychoactive cascade. Instead, CBG is considered a weak and partial agonist of both CB1 and Cannabinoid 2 (CB2) receptors. CB2 receptors are mainly found in the peripheral tissues and immune system, and their activation is not associated with psychoactive effects. CBG also acts on other targets, including the 5-HT1A serotonin receptor, which regulates mood and anxiety.
CBG originates as cannabigerolic acid (CBGA), often called the “mother of all cannabinoids,” because it is the precursor molecule for THC and CBD. By binding weakly to the CB1 receptor, CBG may interfere with THC’s ability to bind. This action effectively limits the psychoactive effects of any co-present THC.
Distinguishable Physical Sensations
While CBG does not produce a euphoric high, users report subtle physical and mental sensations. Many describe the feeling as clear-headed, uplifting, and energizing, sometimes compared to drinking coffee without the jitters. This effect provides a sense of mental sharpness that supports focus and concentration.
Users frequently report an overall sense of physical ease, including relaxation and comfort without causing sedation or drowsiness. The subjective experiences focus on mental clarity and balance, making CBG popular for daytime use or activities requiring sustained attention. This distinct lack of fogginess or lethargy allows individuals to remain fully functional while experiencing a mild sense of calm.