Does an ANA Test Take Longer if Positive?

The ANA Test Process

The process for an Antinuclear Antibody (ANA) test begins with a standard blood collection, typically from a vein in the arm. Once collected, the blood sample is sent to a laboratory for analysis, often using a method called indirect immunofluorescence (IIF) or enzyme-linked immunosorbent assay (ELISA) to detect antinuclear antibodies.

Results are compiled into a report after analysis. The time it takes to receive ANA test results can vary depending on the specific laboratory and whether the sample needs to be sent out to a specialized facility. Generally, results are available within a few business days to about a week. Some labs may provide results within 24 hours, while others might take up to 10 days.

Positive Results and Processing Time

A common question arises regarding whether a positive ANA test result prolongs the initial laboratory processing time. The detection method for antinuclear antibodies in the lab remains consistent, regardless of whether the antibodies are present or not. Therefore, the presence of a positive result does not inherently make the blood sample’s initial processing take more time within the laboratory itself.

Any perceived delay in receiving results from a positive ANA test is not due to the primary analytical phase. Instead, it typically stems from subsequent actions that occur after the initial finding.

Next Steps After a Positive Result

While the initial laboratory processing time for an ANA test is not extended by a positive result, the patient’s journey following such a finding can indeed seem longer. A positive ANA test often prompts healthcare providers to order additional, more specific tests to identify particular autoantibodies. This subsequent testing, known as an Extractable Nuclear Antigen (ENA) panel or individual tests like anti-double-stranded DNA (anti-dsDNA) antibodies, aims to pinpoint the specific type of autoimmune condition, as a positive ANA alone does not confirm a diagnosis.

These follow-up tests, performed on the same blood sample or a new one, require their own processing time, which naturally extends the overall waiting period for a comprehensive understanding. Once all results are available, time is also needed for doctor consultation. The physician interprets the findings in conjunction with the patient’s symptoms and medical history. This detailed evaluation and the development of a diagnosis or treatment plan contribute to the extended timeline experienced by the patient.