N,N-Dimethyltryptamine, commonly known as DMT, is a naturally occurring psychedelic compound found in various plants and animals, including humans. It is recognized for its capacity to induce rapid and intense alterations in perception, thought, and mood. This substance typically creates a brief yet profound experience, often described as an immersive “trip” due to its quick onset and relatively short duration.
How DMT is Taken
DMT exists in several forms, most commonly as a freebase or a fumarate salt. The freebase form is preferred for vaporization or smoking due to its lower boiling point, which results in a cooler, less harsh vapor. It can be vaporized in a glass pipe or dissolved in e-cigarette liquid for use in vape pens. This method allows for quick and efficient administration, with effects typically felt within 10 to 45 seconds.
Oral consumption of DMT is generally ineffective on its own because the body’s monoamine oxidase (MAO) enzymes rapidly metabolize it in the gut and liver. To bypass this rapid breakdown, DMT is often combined with a monoamine oxidase inhibitor (MAOI). This combination is found in traditional Amazonian brews like ayahuasca, where DMT-containing plants are boiled with MAOI-containing vines such as Banisteriopsis caapi. Changa is another preparation where DMT freebase is added to plant material, often containing MAOIs, and then smoked or vaporized. Less common methods of administration include insufflation (snorting) or injection.
Typical Dosage Ranges
The dosage of DMT varies significantly depending on the method of administration, influencing both the intensity and duration of effects. When vaporized or smoked, effective doses are relatively small. A threshold dose, where noticeable effects begin, can be as low as 2 to 10 milligrams.
Common doses for vaporized DMT typically range from 20 to 30 milligrams, producing a mild experience where a user may still relate to their surroundings. Stronger experiences, often referred to as “breakthrough” doses, usually involve 30 to 50 milligrams or more. Doses can be as high as 100 milligrams for smoked or inhaled free-base DMT.
Oral consumption of DMT, usually as part of ayahuasca or pharmahuasca, involves much higher quantities of the compound due to the presence of MAOIs. A typical dose of ayahuasca can contain the equivalent of 24 to 50 milligrams of DMT in about 100 milliliters of brew. Pharmahuasca, a synthetic combination of DMT and an MAOI like moclobemide, might involve around 75 milligrams of pure DMT alongside 150 milligrams of moclobemide. For changa, a smoked blend, doses typically range from 60 to 100 milligrams, which is equivalent to 30 to 50 milligrams of DMT.
Experiencing Different Dose Levels
The subjective experience of DMT is highly dose-dependent, ranging from subtle shifts to profound, immersive states. At lower, threshold doses, individuals may experience mild perceptual alterations, such as slight visual distortions, a sense of euphoria, or subtle changes in body sensations.
As the dose increases to common or moderate levels, visual hallucinations become more pronounced, encompassing both open and closed-eye visuals. Users often report seeing complex patterns and vibrant colors, and their perception of space and time may become altered. Emotional shifts and altered thought patterns are also commonly reported, leading to a more introspective experience.
At strong or “breakthrough” doses, the experience can be exceptionally profound and often defies description. Individuals may encounter highly vivid and intricate alternate realities, sometimes involving interactions with seemingly autonomous entities. This level of experience can lead to ego dissolution, a temporary loss of one’s sense of self, and a complete detachment from ordinary reality. These experiences are often described as feeling like hours or lifetimes, even though the actual duration is brief.
Safe Dosing Practices
Responsible use of DMT necessitates adherence to specific harm reduction guidelines. It is generally advised to “start low and go slow” with dosing, especially for those new to the substance, to assess individual sensitivity. The mental state and physical environment, often referred to as “set and setting,” significantly influence the experience and should be carefully considered to promote a positive outcome.
Combining DMT with other substances can lead to dangerous interactions, including the potential for serotonin syndrome. Having a sober sitter present is recommended to provide support and assistance if the experience becomes overwhelming. Individuals should also be aware of their unique sensitivities, as responses to DMT can vary widely. N,N-Dimethyltryptamine is a Schedule I controlled substance in the United States under the Controlled Substances Act, meaning it is illegal to manufacture, buy, possess, or distribute. Informed decision-making and responsible practices are important when considering any substance use.