Dapoxetine is a medication specifically developed for adult men to address certain concerns related to sexual health. It is available in various strengths, including 60mg tablets, and is intended for use as needed rather than on a daily schedule. This medication belongs to a class of drugs known as selective serotonin reuptake inhibitors, though its application differs from those typically used for mood disorders.
Understanding Dapoxetine’s Purpose
Dapoxetine is approved for the treatment of premature ejaculation (PE) in men aged 18 to 64 years. PE is characterized by ejaculation that occurs too quickly with minimal sexual stimulation, either before, during, or shortly after penetration, and before the individual desires. This condition can lead to personal distress and difficulties in sexual relationships. The medication aims to increase the time it takes to ejaculate and enhance a man’s perceived control over ejaculation, which helps reduce frustration and improve sexual satisfaction.
How Dapoxetine Works in the Body
Dapoxetine functions as a selective serotonin reuptake inhibitor (SSRI), a type of medication that affects neurotransmitters in the brain. It works by increasing the concentration of serotonin in the brain.
Elevated serotonin levels in certain brain regions, particularly those involved in the central ejaculatory neural circuit, are believed to exert an inhibitory effect on ejaculation. This modulation of serotonin activity helps to delay the ejaculatory reflex, thereby prolonging the time to ejaculation. Unlike other SSRIs used for depression, dapoxetine is absorbed and eliminated rapidly, making it suitable for on-demand use rather than continuous daily treatment.
Taking Dapoxetine 60mg Correctly
Dapoxetine 60mg is typically taken orally with at least one full glass of water, approximately 1 to 3 hours before anticipated sexual activity. It is important to swallow the tablet whole to avoid its bitter taste. The medication can be taken with or without food, as food intake does not significantly affect its absorption.
The 60mg dosage is generally not the initial starting dose for dapoxetine. Most healthcare providers will begin treatment with a 30mg tablet. If the response to the 30mg dose is insufficient and the individual has not experienced moderate or severe side effects, particularly symptoms suggesting fainting, the dose may be increased to a maximum of 60mg. Do not exceed one tablet within any 24-hour period.
Possible Side Effects and What to Do
Taking dapoxetine can lead to various side effects, with some being more common than others. Frequently reported side effects include nausea, dizziness, headache, and dry mouth. Other common effects can include diarrhea and insomnia. These reactions are often mild and may lessen over time or with continued use.
Less common but more serious side effects can occur, such as syncope, which is a temporary loss of consciousness often related to a sudden drop in blood pressure. This risk increases with higher doses or if combined with alcohol. Other serious effects that warrant immediate medical attention include signs of an allergic reaction like a swollen face, lips, or tongue, difficulty breathing, or widespread itchy skin rashes. Any significant changes to mood, thoughts of self-harm, or seizures also require prompt medical consultation. If you experience persistent or severe side effects, it is important to contact your doctor for guidance.
Important Warnings and Interactions
Dapoxetine is not suitable for everyone and has specific contraindications. Individuals with certain heart conditions, such as heart failure, conduction abnormalities like AV block or sick sinus syndrome, or significant ischemic heart disease, should not use this medication. It is also contraindicated for those with moderate to severe liver impairment (Child-Pugh class B and C) due to how the drug is metabolized in the body.
Combining dapoxetine with certain other medications can lead to serious interactions. Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOI therapy is prohibited, as this can increase the risk of serotonin syndrome, a potentially life-threatening condition. Similarly, potent CYP3A4 inhibitors, such as ketoconazole, ritonavir, and telithromycin, should be avoided, and grapefruit juice should not be consumed within 24 hours before taking dapoxetine, as these can significantly increase dapoxetine levels in the bloodstream. Caution is also advised when taking other selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), or thioridazine, due to the potential for adverse effects or serotonin syndrome.