Coleus forskohlii is a plant with a rich history in traditional medicine, particularly in Ayurvedic systems, where it has been used for centuries for various health purposes. Its increasing popularity highlights a growing interest in natural compounds and their potential benefits.
What is Coleus Forskohlii
Coleus forskohlii is an herbaceous perennial belonging to the mint family (Lamiaceae). This plant is native to subtropical regions, thriving in countries like India, Nepal, Thailand, and Sri Lanka. Historically, it has been a significant component of Ayurvedic medicine, where its roots were traditionally utilized for their perceived medicinal properties.
The plant typically grows to about 1 to 2 feet tall, featuring an erect stem and thick, fibrous, golden-brown tuberous roots. Its leaves are often described as teardrop-shaped, shimmering green, sometimes with a bright purple center, and it produces pale purple or blue flowers. The roots are the most valued part of the plant in phytotherapy, as they contain the primary active compounds.
The Active Compound Forskolin
The primary bioactive compound responsible for Coleus forskohlii’s effects is forskolin. Forskolin is a labdane diterpene. It is predominantly extracted from the thick, tuberous roots of the Coleus forskohlii plant.
Forskolin is recognized for its unique chemical structure and its significant role as the key active ingredient in Coleus forskohlii extracts.
Potential Benefits of Coleus Forskohlii
Coleus forskohlii and its active compound, forskolin, are associated with several potential health benefits. One frequently discussed area is weight management, where it may help in increasing lean body mass and reducing body fat percentage. This plant extract is thought to support metabolism, contributing to more efficient fat burning.
Another potential benefit lies in supporting cardiovascular health. Forskolin’s properties may help relax blood vessels, improve blood flow, and contribute to reducing blood pressure. It has also been traditionally used and researched for its role in respiratory health. This includes potentially aiding in the relaxation of bronchial muscles, which could make breathing easier and alleviate symptoms associated with certain respiratory conditions like asthma.
How Coleus Forskohlii Works
Forskolin primarily exerts its effects by activating adenylate cyclase. This activation leads to an increase in the intracellular levels of cyclic adenosine monophosphate, commonly known as cAMP. cAMP acts as a crucial “second messenger” within cells, playing a significant role in various biological processes.
Increased cAMP levels can influence numerous cellular functions. For instance, in the context of weight management, higher cAMP levels can stimulate the breakdown of stored fats. In the respiratory system, this mechanism contributes to the relaxation of smooth muscles in the airways, promoting easier breathing. The ability of forskolin to elevate cAMP levels impacts a wide range of physiological responses, linking its cellular action to its potential benefits.
Safety and Dosage
When considering Coleus forskohlii supplements, understanding dosage and safety is important. Standardized extracts typically contain 10% to 20% forskolin. A common dosage is 250 mg of a 10% forskolin extract taken twice daily, totaling 500 mg daily. For asthma, oral forskolin has been studied at 10 mg daily for several months.
Potential side effects can occur, including low blood pressure, especially for individuals already taking blood-pressure-lowering medications. Other reported side effects might include stomach upset, such as diarrhea, constipation, or vomiting. It is also suggested that forskolin might increase the risk of bleeding in some individuals.
Those with low blood pressure, bleeding disorders, or taking blood-thinning medications should exercise caution or avoid Coleus forskohlii. Pregnant or nursing women are advised against its use, as information regarding safety in these groups is limited. Consulting a healthcare professional before starting any new supplement is important to ensure it is appropriate for individual health conditions and to discuss any potential interactions with existing medications.