Cissus Quadrangularis, an ancient plant used in traditional medicine, is gaining attention for its potential role in weight management. This article explores the scientific understanding of Cissus Quadrangularis and its possible contributions to weight loss.
What is Cissus Quadrangularis?
Cissus Quadrangularis is a perennial plant in the grape family (Vitaceae), native to parts of Africa and Asia, including India. It is known by names like Devil’s Backbone, Veldt Grape, or “Asthisamharaka” (Sanskrit for “bone setter”), highlighting its historical use. This succulent vine has been used in traditional healing systems, especially Ayurvedic medicine.
Cissus Quadrangularis has a long history of traditional uses beyond weight loss. It has been employed to promote bone healing, manage joint pain, and address digestive issues. Traditional practices also incorporated it for conditions like asthma and hemorrhoids.
How Cissus Quadrangularis May Aid Weight Loss
Cissus Quadrangularis may contribute to weight loss through several biological pathways. One proposed action is its ability to influence appetite regulation. The plant may help suppress hunger by affecting serotonin levels, a neurotransmitter involved in satiety. This could lead to reduced calorie intake by promoting a feeling of fullness.
Cissus Quadrangularis may also interfere with the body’s ability to absorb dietary fats. Compounds within the plant, such as phytosterols and fiber extracts, may possess anti-lipase properties, reducing fat absorption from the digestive tract. This suggests less consumed fat would be stored as body fat. Additionally, some research indicates Cissus Quadrangularis could modulate lipid metabolism and inhibit adipogenesis, the process of fat cell formation.
Scientific Evidence Supporting Weight Loss Claims
Scientific studies have investigated the effects of Cissus Quadrangularis on weight loss, with some promising results. A double-blind, placebo-controlled study involving 168 overweight and obese participants showed that a Cissus Quadrangularis extract (CQR-300), taken at 300 mg daily over eight weeks, led to significant reductions in body weight, body fat, and cholesterol levels. This study also noted an increase in plasma serotonin levels, supporting the hypothesis of appetite control.
Another randomized, double-blind, placebo-controlled trial with 123 overweight and obese individuals, using a Cissus Quadrangularis formulation, also demonstrated significant reductions in weight and central obesity, including waist circumference, over an eight-week period. Participants in this study, regardless of adhering to a calorie-controlled diet, experienced improvements in fasting blood glucose, total cholesterol, LDL-cholesterol, and triglycerides. While these human trials suggest a positive effect, the overall body of research is still relatively small, and more extensive studies are needed to confirm these findings across diverse populations.
Animal studies have further explored the anti-obesity effects, showing that Cissus Quadrangularis extracts can reduce body fat mass by inhibiting lipase activity and regulating genes involved in fat storage and formation. For instance, in mice fed a high-fat diet, Cissus Quadrangularis administration resulted in marked reductions in body weight gain, adipose tissue mass, and hepatic lipid accumulation. This suggests potential benefits in reducing fat accumulation and improving liver health in the context of obesity.
Safe Usage and Potential Side Effects
Cissus Quadrangularis is generally considered safe for most individuals when used appropriately. It is commonly available in various forms, including capsules, extracts, and powders. While there is no universally established official dosage, many supplements recommend doses ranging from 500 to 1,000 mg per day. However, some studies have explored dosages between 300 mg and 3,200 mg daily, reporting benefits within this range.
It is advisable to begin with a lower dose and gradually increase it to assess individual tolerance. Mild side effects have been reported in some cases, which may include digestive issues such as gas, diarrhea, or mild stomach upset. Other less common side effects can include headaches or insomnia.
Pregnant or breastfeeding individuals should avoid Cissus Quadrangularis due to limited safety research. It may also lower blood sugar levels, so those taking diabetes medications should use caution and consult a healthcare professional. Always discuss any new supplement with a healthcare provider, especially if you have pre-existing medical conditions or take other medications.