Can Tizanidine Cause Anxiety and What to Do

Tizanidine is a medication prescribed primarily as a muscle relaxant. It is used to manage and relieve muscle spasms, cramping, and tightness often associated with conditions like multiple sclerosis or spinal cord injuries. This medication helps reduce the involuntary contraction of muscles, which can be both painful and debilitating.

How Tizanidine Works

Tizanidine works by acting on the central nervous system, specifically by stimulating alpha-2 adrenergic receptors located in the brain and spinal cord. This action inhibits the release of certain excitatory neurotransmitters, such as norepinephrine, which are responsible for transmitting nerve signals that cause muscle contractions. The drug primarily affects spinal polysynaptic reflexes, which involve multiple neurons communicating to control muscle movement.

The Link Between Tizanidine and Anxiety

Tizanidine can cause anxiety as a side effect. This might be related to its broad effects on the central nervous system and neurotransmitter balance, although the precise mechanism for drug-induced anxiety can vary among individuals.

Anxiety can also manifest as a symptom of tizanidine withdrawal. If the medication is stopped suddenly, especially after long-term use, the body may experience a rebound effect. Withdrawal symptoms, including anxiety, increased heart rate, and tremors, can occur because the body has adapted to the drug’s presence.

Coping with Anxiety on Tizanidine

If you experience anxiety while taking tizanidine, it is important to consult your doctor. Your doctor may consider adjusting your dosage, as taking too high a dose could contribute to side effects.

A healthcare professional might also explore alternative medications for muscle spasticity that may have a different side effect profile. Additionally, supportive measures like stress reduction techniques could be discussed as part of a broader management plan, but only under medical guidance. The goal is to manage muscle spasms effectively while minimizing unwanted effects like anxiety.

When to Consult a Doctor

You should contact your doctor immediately if you experience severe anxiety or any other concerning symptoms while taking tizanidine. Signs that warrant prompt medical attention include confusion, hallucinations, or a light-headed feeling. It is also important to seek medical advice if you notice yellowing of the skin or eyes, pain in the upper right stomach, or unusual bleeding, as these could indicate a serious liver problem.

Never stop taking tizanidine suddenly without your doctor’s guidance, as this can lead to withdrawal symptoms such as increased muscle stiffness, high blood pressure, and a fast heartbeat. Your doctor can provide a plan to gradually reduce the dosage, if necessary, to help prevent these reactions. Other common side effects like drowsiness, dry mouth, or dizziness are generally less severe, but should still be discussed with your healthcare provider if they are bothersome or persist.