Can Morton’s Neuroma Come Back After Surgery?

Morton’s Neuroma (MN) is a common condition involving a thickening of the tissue that surrounds a digital nerve in the foot, most frequently occurring between the third and fourth toes. This enlargement causes persistent forefoot pain, often described as feeling like walking on a marble or a bunched-up sock. When conservative treatments like orthotics and injections fail, surgery is often considered, typically involving either nerve removal (neurectomy) or decompression. While primary surgical intervention is highly effective, pain can return. This article addresses the nature of post-surgical issues, distinguishing between a successful recovery and the development of new or persistent pain.

The Possibility of Recurrence

The direct answer to whether Morton’s Neuroma can return after surgery is complex, but post-surgical pain can certainly persist or develop later. Primary neurectomy has a high success rate, with 80% to 95% of patients reporting good to excellent outcomes. However, a small percentage of patients, estimated to be between 4% and 35%, experience continued or new pain after the initial operation.

It is important to distinguish between pain that never fully resolved and pain that returns months or years later. Pain that persists immediately after recovery suggests an incomplete resolution or an underlying issue that was not fully addressed. True recurrence, manifesting long after the surgical site has healed, points to a new biological process requiring further medical evaluation.

Mechanisms Causing Post-Surgical Pain

The most common mechanism for post-surgical pain is the formation of a stump neuroma. This occurs when the cut end of the nerve, removed during neurectomy, attempts to regenerate in a disorganized manner. The body’s natural healing response causes nerve fibers to sprout, forming a painful, fibrous ball of tissue at the nerve’s severed end.

This abnormal growth becomes a source of pain, particularly if it is situated close to the skin or scar tissue where it can be compressed or irritated by walking. The disorganized nerve endings become hypersensitive, transmitting pain signals to the brain. This condition is considered a specific type of recurrent neuroma related to the surgical procedure itself.

Other factors contribute to post-operative pain, including nerve entrapment within scar tissue at the surgical site. The formation of restrictive adhesions around the remaining nerve stump can cause compression and irritation, even without a significant stump neuroma forming. In some instances, the initial diagnosis may have been incorrect, and the persistent pain may be due to an entirely different condition that mimics Morton’s Neuroma, such as a stress fracture or metatarsalgia. Incomplete excision, where a small portion of the original neuroma was missed or the nerve was not adequately recessed into softer tissue, can also lead to unresolved symptoms.

Recognizing Symptoms of Recurrence

Recognizing the symptoms of true recurrence or stump neuroma involves noting the quality and location of the pain. The classic symptoms of nerve pain, such as the sharp, burning, or “electric shock” sensation, often return, indicating nerve involvement. This neuropathic pain is typically localized to the area of the surgical incision and the web space between the toes.

A specific sign of a stump neuroma is localized tenderness when pressure is applied, sometimes accompanied by a palpable lump. The pain is often felt 1 to 1.5 centimeters proximal to the original neuroma site. It is important to distinguish this from general post-operative soreness or swelling, which should gradually resolve within the typical three to four-month recovery period. If sharp, nerve-related symptoms persist beyond this timeline or reappear months later, recurrence should be suspected.

Secondary Treatment Pathways

If post-surgical pain or recurrence is confirmed, the treatment pathway typically begins with conservative methods. This may include using custom-molded orthotics to redistribute pressure away from the affected forefoot area. Targeted injections of local anesthetic, sometimes combined with a steroid, can also be used as both a diagnostic and temporary therapeutic option.

If conservative treatments prove ineffective, minimally invasive procedures are often considered before a second surgery. These options may include cryoablation, which uses extreme cold to destroy the painful nerve tissue, or radiofrequency ablation, which uses heat for the same purpose. Should these methods fail to provide lasting relief, a revision neurectomy may be necessary to remove the painful stump neuroma.

During a revision surgery, the goal is to cleanly excise the painful stump and then implant the remaining nerve end into deep soft tissue, such as muscle or bone, to prevent irritation from pressure. Treatment for recurrence is often more intricate than the primary surgery, emphasizing the need for an accurate diagnosis to ensure the underlying cause is addressed effectively. Emerging techniques, such as Targeted Muscle Reinnervation, are also being explored in specialized centers.