Can Licorice Cause Diarrhea? What Science Says

Licorice, a plant with roots valued for their distinctive flavor and medicinal properties, has been used for centuries as a flavoring agent and in traditional remedies. It is found in products ranging from candies to herbal supplements. Many people wonder about its effects on the digestive system, particularly whether it can cause diarrhea. While licorice root is sometimes used to address constipation, consuming certain types and amounts can indeed lead to loose stools.

The Link Between Licorice and Diarrhea

The connection between licorice and diarrhea stems from glycyrrhizin, a compound naturally present in licorice root extract. Glycyrrhizin has a structure similar to aldosterone, a hormone regulating fluid and electrolyte balance. This allows glycyrrhizin to mimic aldosterone’s effects, influencing sodium and potassium levels.

When consumed in sufficient quantities, glycyrrhizin can affect the balance of water and electrolytes in the intestinal tract. It can lead to increased fluid secretion into the intestines and reduced water reabsorption. This creates an osmotic effect, where water is drawn into the bowel, softening the stool. The enhanced fluid content and altered electrolyte balance can stimulate bowel movements, resulting in diarrhea.

Factors Influencing Diarrhea Risk

The likelihood of experiencing diarrhea from licorice consumption depends on several factors, including the type of licorice product and the quantity consumed. Many candies marketed as “licorice” do not contain actual licorice root extract. Instead, they often use anise oil for flavoring, which does not contain glycyrrhizin and therefore does not carry the same gastrointestinal risks.

However, products containing real licorice root, such as certain candies, teas, or herbal supplements, will contain glycyrrhizin. The dosage of glycyrrhizin is a primary determinant of its effects. Consuming large quantities or concentrated forms of licorice extract is more likely to induce diarrhea than small amounts. Individual sensitivity also plays a role, as some people may be more susceptible to the laxative effects of glycyrrhizin even at lower doses. The overall daily intake of glycyrrhizin from all sources should be considered when assessing risk.

Other Potential Effects of Licorice Consumption

Beyond its potential to cause diarrhea, excessive licorice consumption, particularly of products high in glycyrrhizin, can lead to other health concerns. One notable effect is an increase in blood pressure, known as hypertension. This occurs because glycyrrhizin interferes with an enzyme that normally breaks down cortisol, leading to higher levels of cortisol in the body, which can, in turn, affect blood pressure regulation.

Another potential consequence is hypokalemia, or abnormally low potassium levels in the blood. Glycyrrhizin’s mineralocorticoid-like activity can cause the kidneys to excrete more potassium, leading to this imbalance. Low potassium levels can manifest as muscle weakness, fatigue, or an irregular heartbeat. Fluid retention, characterized by swelling in the ankles or feet, can also occur due to glycyrrhizin’s influence on fluid balance.

When to Seek Medical Advice

While mild diarrhea from licorice consumption might resolve on its own, certain symptoms warrant medical attention. It is advisable to consult a healthcare provider if diarrhea is severe, persistent, or accompanied by signs of dehydration. Symptoms of dehydration can include excessive thirst, decreased urination, dry mouth, or dizziness.

Additionally, if you experience muscle weakness, irregular heartbeats, or significant swelling after consuming licorice, seeking medical advice is important. These symptoms could indicate more serious electrolyte imbalances or other adverse effects. Discontinuing licorice consumption is often the first step, but professional guidance ensures proper evaluation and management of any health concerns.