Taking supplements to support cardiovascular health has become common, and two substances frequently researched in this area are Nattokinase and Vitamin K2. Nattokinase is an enzyme derived from a traditional Japanese fermented soybean food called natto, while Vitamin K2 is a fat-soluble vitamin. Both are often promoted for their distinct yet complementary roles in circulation and arterial health. The core question for many individuals is whether combining these two powerful supplements is safe and offers enhanced benefits for the heart and blood vessels.
Nattokinase’s Fibrinolytic Action
Nattokinase is a potent enzyme, specifically a serine protease, produced by the bacterium Bacillus subtilis natto during the fermentation of soybeans into natto. Its primary function is to help break down fibrin, the main protein component that forms the mesh structure of a blood clot. The enzyme acts directly by hydrolyzing fibrin, effectively dissolving the clot structure itself. Nattokinase also supports the body’s natural clot-dissolving systems by enhancing fibrinolytic activity. It does this by degrading Plasminogen Activator Inhibitor-1 (PAI-1) and stimulating the release of tissue plasminogen activator (t-PA), which converts plasminogen into plasmin, the body’s natural clot-buster, contributing to improved blood fluidity and reduced blood viscosity.
Vitamin K2 and Calcium Management
Vitamin K2, specifically the menaquinone-7 (MK-7) form, regulates where calcium is deposited in the body. This vitamin acts as a cofactor to activate specific Vitamin K-dependent proteins (VKDPs) through a process called carboxylation. One of these is Matrix Gla Protein (MGP), which, once activated, inhibits soft tissue calcification. The activation of MGP helps prevent calcium from accumulating in artery walls, maintaining arterial flexibility and health.
Simultaneously, K2 activates Osteocalcin, which directs calcium into the bone structure for strength. This dual action promotes bone health while reducing the risk of vascular calcification. Unlike Vitamin K1, which affects the liver’s production of standard blood clotting factors, K2 does not significantly interfere with the blood coagulation cascade.
Evaluating the Combined Use
The combination of Nattokinase and Vitamin K2 is often considered for comprehensive cardiovascular support because their mechanisms are complementary. Nattokinase focuses on improving blood flow by reducing the risk of clot formation and blood viscosity. Vitamin K2 works to improve the physical health of the arteries by inhibiting the calcification and stiffening of vessel walls. This synergistic approach addresses two different aspects of cardiovascular wellness: blood flow dynamics and arterial structure.
The natural food source, natto, contains both Nattokinase and a high amount of Vitamin K2, which suggests a biological compatibility. For healthy individuals not currently taking prescription anticoagulant medication, the combination is generally viewed as safe, provided appropriate dosages are used. The primary concern for combining supplements that affect blood health is the potential for an increased bleeding risk. However, purified Nattokinase supplements are often manufactured with the Vitamin K2 removed, allowing for precise dosing when combining a purified Nattokinase and a separate K2 supplement.
Essential Safety Guidelines
It is recommended to consult a healthcare provider before starting a combined regimen. This is important for individuals with pre-existing conditions or those taking prescription medications. Nattokinase’s blood flow-enhancing effects mean it can interact with anticoagulant and antiplatelet drugs, such as Warfarin or aspirin, potentially increasing the risk of bruising or bleeding.
Vitamin K2 is also a concern for those on Warfarin, a Vitamin K antagonist, as it can reduce the drug’s effectiveness. Individuals with diagnosed bleeding disorders or those scheduled for surgery should avoid Nattokinase; it is recommended to discontinue use at least two weeks before any scheduled procedure. A medical professional can accurately determine the appropriate dosage and assess any contraindications based on an individual’s health status.